Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats

Table 2

Results of aspirin induced ulcerogenesis in pyloric ligation model.

Parameters	Various groups
	Negative control	Ranitidine	Aqueous extract of Channa striata
		50 mg/kg	30% w/v	40% w/v	50% w/v
Volume of gastric juice (mL)	5.43±0.22	4.36±0.17^∗∗	5.26±0.16^ns	4.53±0.16^∗	4.23±0.32^∗∗
pH	3.83±0.108	4.95±0.16^∗∗	3.33±0.33^ns	3.68±0.18^ns	3.65±0.084^ns
Free acidity	51.00±2.85	40.00±2.47^∗	45.00±2.72^ns	44.00±1.59^ns	39.33±2.97^∗
Total acidity	93.17±1.86	85.50±1.40^∗∗	90.50±1.72^ns	90.17±1.74^ns	86.67±1.20^∗
Ulcer index	5.91±0.45	2.75±0.38^∗∗∗	4.00±0.36^∗∗	3.75±0.38^∗∗	3.08±0.35^∗∗∗
Percentage of inhibition	—	53.46%	32.31%	36.54%	47.88%
Catalase (units/mg of tissue)	0.011±0.011	0.059±0.0032^∗∗	0.041±0.0079^ns	0.066±0.0064^∗∗	0.072±0.012^∗∗∗
Superoxide dismutase (units/mg of tissue)	0.015±0.010	0.071±0.0094^∗∗	0.027±0.0050^ns	0.047±0.012^ns	0.055±0.013^∗
Malondialdehyde (moles/mg of tissue)	0.190±0.0012	0.089±0.0013^∗∗∗	0.088±0.0034^∗∗∗	0.085±0.0078^∗∗∗	0.072±0.013^∗∗∗

Note: sample size (𝑛) = 6 rats per group. Data is expressed as mean ± standard error of mean and standard deviation in parenthesis. ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 and ns nonsignificant versus negative control (on statistical analysis with ANOVA, followed by Dunnett’s multiple comparison post hoc test).