Table of Contents
ISRN Neurology
Volume 2014, Article ID 345132, 4 pages
http://dx.doi.org/10.1155/2014/345132
Clinical Study

Serotonin Transporter Availability in Early Stage Parkinson’s Disease and Multiple System Atrophy

1Department of Neurology, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands
2Department of Neurology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
3Department of Nuclear Medicine, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands

Received 7 November 2013; Accepted 23 December 2013; Published 3 February 2014

Academic Editors: A. Conti, K. W. Lange, D. Mathieu, D. Schiffer, and F. G. Wouterlood

Copyright © 2014 S. R. Suwijn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Bernheimer, W. Birkmayer, and O. Hornykiewicz, “Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations,” Journal of the Neurological Sciences, vol. 20, no. 4, pp. 415–455, 1973. View at Publisher · View at Google Scholar · View at Scopus
  2. A. J. Hughes, S. E. Daniel, L. Kilford, and A. J. Lees, “Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases,” Journal of Neurology Neurosurgery and Psychiatry, vol. 55, no. 3, pp. 181–184, 1992. View at Google Scholar · View at Scopus
  3. A. J. Hughes, S. E. Daniel, and A. J. Lees, “Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease,” Neurology, vol. 57, no. 8, pp. 1497–1499, 2001. View at Google Scholar · View at Scopus
  4. J. Jankovic, A. H. Rajput, M. P. McDermott, and D. P. Perl, “The evolution of diagnosis in early Parkinson disease,” Archives of Neurology, vol. 57, no. 3, pp. 369–372, 2000. View at Google Scholar · View at Scopus
  5. E. Tolosa, G. Wenning, and W. Poewe, “The diagnosis of Parkinson's disease,” The Lancet Neurology, vol. 5, no. 1, pp. 75–86, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. J. Hughes, S. E. Daniel, Y. Ben-Shlomo, and A. J. Lees, “The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service,” Brain, vol. 125, no. 4, pp. 861–870, 2002. View at Google Scholar · View at Scopus
  7. I. Litvan, A. MacIntyre, C. G. Goetz et al., “Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study,” Archives of Neurology, vol. 55, no. 7, pp. 969–978, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. R. de la Fuente-Fernandez, “Role of DaTSCAN and clinical diagnosis in Parkinson disease,” Neurology, vol. 78, pp. 696–701, 2012. View at Google Scholar
  9. A. M. M. Vlaar, M. J. P. G. van Kroonenburgh, A. G. H. Kessels, and W. E. J. Weber, “Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes,” BMC Neurology, vol. 7, article 27, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Antonini, R. Benti, R. De Notaris et al., “123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy,” Neurological Sciences, vol. 24, no. 3, pp. 149–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Varrone, K. L. Marek, D. Jennings, R. B. Innis, and J. P. Seibyl, “[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy,” Movement Disorders, vol. 16, no. 6, pp. 1023–1032, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Farde, C. Halldin, L. Muller, T. Suhara, P. Karlsson, and H. Hall, “PET study of [11C]β-CIT binding to monoamine transporters in the monkey and human brain,” Synapse, vol. 16, no. 2, pp. 93–103, 1994. View at Google Scholar · View at Scopus
  13. E. C. Hirsch, G. Orieux, M.-P. Muriel, C. Francois, and J. Feger, “Nondopaminergic neurons in Parkinson's disease,” Advances in Neurology, vol. 91, pp. 29–37, 2003. View at Google Scholar · View at Scopus
  14. S. J. Kish, J. Tong, O. Hornykiewicz et al., “Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease,” Brain, vol. 131, no. 1, pp. 120–131, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Roselli, N. M. Pisciotta, M. Pennelli et al., “Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study,” Movement Disorders, vol. 25, pp. 1853–1859, 2010. View at Google Scholar
  16. C. Scherfler, K. Seppi, E. Donnemiller et al., “Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease,” Brain, vol. 128, no. 7, pp. 1605–1612, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Pirker, S. Asenbaum, M. Hauk et al., “Imaging serotonin and dopamine transporters with 123I-β-CIT SPECT: binding kinetics and effects of normal aging,” Journal of Nuclear Medicine, vol. 41, no. 1, pp. 36–44, 2000. View at Google Scholar · View at Scopus
  18. M. M. L. de Win, J. B. A. Habraken, L. Reneman, W. Van Den Brink, G. J. Den Heeten, and J. Booij, “Validation of [123I]β-CIT SPECT to serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram,” Neuropsychopharmacology, vol. 30, no. 5, pp. 996–1005, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Laruelle, R. M. Baldwin, R. T. Malison et al., “SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT: pharmacological characterization of brain uptake in nonhuman primates,” Synapse, vol. 13, no. 4, pp. 295–309, 1993. View at Google Scholar · View at Scopus
  20. J. L. Neumeyer, S. Wang, Y. Gao et al., “N-ω-fluoroalkyl analogs of (1R)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane (β-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters,” Journal of Medicinal Chemistry, vol. 37, no. 11, pp. 1558–1561, 1994. View at Google Scholar · View at Scopus
  21. W. R. G. Gibb and A. J. Lees, “The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease,” Journal of Neurology Neurosurgery and Psychiatry, vol. 51, no. 6, pp. 745–752, 1988. View at Google Scholar · View at Scopus
  22. A. J. Hughes, Y. Ben-Shlomo, S. E. Daniel, and A. J. Lees, “What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study,” Neurology, vol. 42, no. 6, pp. 1142–1146, 1992. View at Google Scholar · View at Scopus
  23. D. Stoffers, J. Booij, L. Bosscher, A. Winogrodzka, E. C. Wolters, and H. W. Berendse, “Early-stage [123I]β-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 32, no. 6, pp. 689–695, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Tissingh, P. Bergmans, J. Booij et al., “Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]β-CIT SPECT,” Journal of Neurology, vol. 245, no. 1, pp. 14–20, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Boot, J. Booij, G. Hasler et al., “AMPT-induced monoamine depletion in humans: evaluation of two alternative [123I]IBZM SPECT procedures,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 35, no. 7, pp. 1350–1356, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. R. B. Innis, V. J. Cunningham, J. Delforge et al., “Consensus nomenclature for in vivo imaging of reversibly binding radioligands,” Journal of Cerebral Blood Flow and Metabolism, vol. 27, no. 9, pp. 1533–1539, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Pirker, S. Djamshidian, S. Asenbaum et al., “Progression of dopaminergic degeneration in Parkinson's disease and atypical parkinsonism: a longitudinal β-CIT SPECT study,” Movement Disorders, vol. 17, no. 1, pp. 45–53, 2002. View at Publisher · View at Google Scholar · View at Scopus