Serotonin Transporter Availability in Early Stage Parkinson’s Disease and Multiple System Atrophy

Table 2

Mean specific to nonspecific [¹²³I]𝛽-CIT midbrain binding ratio (BP_ND) (mean ± SD) and midbrain SERT-to-striatal DAT ratios.

Region of interest	PD; (𝑛=50)	MSA; (𝑛=7)	𝑃-value
Midbrain	1.03±0.37	1.21±0.38	0.28
Striatum, whole	4.08±0.27	4.15±0.42	0.93
Caudate nucleus	5.79±1.84	6.38±2.67	0.78
Putamen	3.15±0.97	3.41±1.33	0.52
Midbrain/putamen	0.36±0.13	0.40±0.11	0.44
Midbrain/caudate nucleus	0.18±0.06	0.22±0.06	0.09
Midbrain/striatum	0.26±0.09	0.34±0.14	0.048

SERT: serotonin transporter, DAT: dopamine transporter, SD: standard deviation, PD: Parkinson’s disease, and MSA: multiple system atrophy.