Research Article

Effect of Analgesics on Monoclonal Antibody Ascites Production in Mice Administered Upon Recognition of Pain

Table 3

Analgesic treatments given upon recognition of clinical signs.

GroupCage IDTreatments givenTreatments given on days after hybridoma cell injectionsa
0–4b567
AMPMAMPMcAMPMAMPMd

AA1, A20.9% saline++++

BB1, B2Meloxicam++
Saline++

CC1, C2Buprenorphine++++
Buprenorphine++++

DD1Meloxicam++
Buprenorphine++++
D2Meloxicam ++
Buprenorphine+++

Treatments denoted with − indicate that the treatment was not given and + indicates that the treatment was given. bHybridoma cells were injected on day 0. cThe treatments were given after the first ascites fluid collection conducted on the evening of Day 5. dAll mice were euthanized, prior to the second and final ascites fluid collection on the evening of day 7.