Interaction of Hepatitis C Viral Proteins with Cellular Oncoproteins in the Induction of Liver Cancer

Table 1

Comparison of the roles played by p53 and YB-1 in various cellular processes. Note that both proteins are actively involved in all the events that lead to cell proliferation and apoptosis, DNA damage and repair, genomic stability, and transcriptional regulation. Unlike p53, YB-1 plays an important role in translational regulation of various mRNAs, in inducing multidrug resistance especially in cancers. Another major difference between p53 and YB-1 is that the YB-1 knockout mice are embryonic lethal due to defects in translation of mRNAs and cell proliferation, whereas p53 knockout mice are prone to cancer without affecting normal embryonic development.

Role in cellular processes
	p53	YB-1
Oncogene activation	+	+
DNA damage	+	+
DNA Repair	+	+
Genomic stability	+	+
Apoptosis	+	+
Hypoxia	+	+
Cell cycle arrest	+	+
Transcriptional regulation	+	+
Translational regulation	−	+
Ribosomal stress	+	−
Drug resistance	−	+
Redox signaling	−	+
Knockout	Prone to cancer	Embryonic lethal