Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats

Table 2

Effect of maprotiline (Map. 10, 20, and 40 mg/kg) on changes in the body weight in the indicated conditions.

Group	Sham	Control	Dex. 1	RSP	Map. 10	Map. 20	Map. 40
Body weight changes after four days (g)	8.8 ± 2.3	−22.5 ± 5.3	0.3 ± 5.1	−30.2 ± 2.8	−18.7 ± 5.1	−7.3 ± 6.8	−13.5 ± 3.1

Dex. 1: dexamethasone (1 mg/kg), RSP: reserpine (6 mg/kg), and i.p.: intraperitoneally. Animals were also reserpinised (6 mg/kg, i.p.) depressed. Results are expressed as mean ± SEM of six rats in each group. , , and compared to Sham group; one-way ANOVA followed by Tukey’s test.