Table of Contents
ISRN Endocrinology
Volume 2014, Article ID 374090, 8 pages
Clinical Study

Serum Levels of the Adipokine Zinc-α2-glycoprotein Are Decreased in Patients with Hypertension

Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, The Translational Medicine Center of PUMCH, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Received 21 August 2013; Accepted 22 December 2013; Published 9 February 2014

Academic Editors: S. M. Hileman and J. Nedvidkova

Copyright © 2014 Hui Juan Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Zinc- 2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight regulation. The purpose of this study is to investigate serum levels of ZAG in patients with hypertension and its association with related characteristics. Methods. 32 hypertension patients and 42 normal controls were recruited and the relationship between serum ZAG, total and high molecular weight (HMW) adiponectin, and tumor necrosis factor- (TNF ) determined by enzyme-linked immunosorbent assay (ELISA) and metabolic-related parameters was investigated. Results. Serum ZAG concentrations were significantly lowered in patients with hypertension compared with healthy controls (61.4 ± 32 versus 78.3 ± 42  g/mL, ). The further statistical analysis demonstrated that serum ZAG levels were negatively correlated with waist-to-hip ratio (WHR) ( , ) and alanine aminotransferase (ALT) ( , ). Additionally, serum HMW adiponectin significantly decreased, while TNF greatly increased in hypertension patients as compared with healthy controls (2.32 ± 0.41 versus 5.24 ± 1.02  g/mL, 3.30 ± 1.56 versus 2.34 ± 0.99 pg/mL, ). Conclusions. Serum ZAG levels are significantly lowered in hypertension patients and negatively correlated with obesity-related item WHR, suggesting ZAG is a factor associated with hypertension.