Table of Contents
ISRN Obstetrics and Gynecology
Volume 2014, Article ID 381826, 6 pages
http://dx.doi.org/10.1155/2014/381826
Clinical Study

Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution

1Department of Clinical Haematology, Launceston General Hospital, Launceston, TAS 7250, Australia
2Department of Medicine, Launceston General Hospital, Launceston, TAS 7250, Australia
3School of Human Life Sciences, University of Tasmania, Launceston, TAS 7250, Australia
4Menzies Research Institute, Hobart, TAS 7000, Australia
5Department of Obstetrics and Gynaecology, Launceston General Hospital, Launceston, TAS 7250, Australia

Received 10 October 2013; Accepted 26 November 2013; Published 17 February 2014

Academic Editors: M. Kühnert, P. Pacora, and S. Palomba

Copyright © 2014 Alhossain A. Khalafallah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Hellgren and M. Blomback, “Studies on blood coagulation and fibrinolysis in pregnancy, during delivery and in the puerperium. I. Normal condition,” Gynecologic and Obstetric Investigation, vol. 12, no. 3, pp. 141–154, 1981. View at Google Scholar · View at Scopus
  2. Y. Stirling, L. Woolf, and W. R. S. North, “Haemostasis in normal pregnancy,” Thrombosis and Haemostasis, vol. 52, no. 2, pp. 176–182, 1984. View at Google Scholar · View at Scopus
  3. K. A. Bremme, “Haemostatic changes in pregnancy,” Best Practice and Research, vol. 16, no. 2, pp. 153–168, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Hellgren, “Hemostasis during normal pregnancy and puerperlum,” Seminars in Thrombosis and Hemostasis, vol. 29, no. 2, pp. 125–130, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. P. W. Friederich, B. J. Sanson, P. Simioni, S. Zanardi, M. V. Huisman, and I. Kindt, “Frequency of pregnancy-related venous thromboemboolism in anticoagulant factor-deficient women: implications for prophylaxis,” Annals of Internal Medicine, vol. 125, no. 12, pp. 955–960, 1996. View at Publisher · View at Google Scholar
  6. M. D. McColl, J. E. Ramsay, R. C. Tait et al., “Risk factors for pregnancy associated venous thromboembolism,” Thrombosis and Haemostasis, vol. 78, no. 4, pp. 1183–1188, 1997. View at Google Scholar · View at Scopus
  7. N. Folkeringa, J. L. P. Brouwer, F. J. Korteweg, N. J. G. M. Veeger, J. J. H. M. Erwich, and J. van der Meer, “High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects,” British Journal of Haematology, vol. 138, no. 1, pp. 110–116, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. I. A. Greer, “Thrombosis in pregnancy: maternal and fetal issues,” The Lancet, vol. 353, no. 9160, pp. 1258–1265, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Gerhardt, R. E. Scharf, M. W. Beckmann et al., “Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium,” The New England Journal of Medicine, vol. 342, no. 6, pp. 374–380, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. C. S. Gibson, A. H. MacLennan, N. G. Janssen et al., “Associations between fetal inherited thrombophilia and adverse pregnancy outcomes,” American Journal of Obstetrics and Gynecology, vol. 194, no. 4, pp. 947.e1–947.e10, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Alfirevic, D. Roberts, and V. Martlew, “How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 101, no. 1, pp. 6–14, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. “Thrombosis and Embolism during Pregnancy and the Puerperium, Reducing the Risk (Green-top 37a),” 2009, http://www.rcog.org.uk/womens-health/clinical-guidance/reducing-risk-of-thrombosis-greentop37a.
  13. S. M. Bates, I. A. Greer, I. Pabinger, S. Sofaer, and J. Hirsh, “Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition),” Chest, vol. 133, supplement 6, pp. 844S–886S, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. E. Warren, S. E. Simonsen, D. W. Branch, T. F. Porter, and R. M. Silver, “Thromboprophylaxis and pregnancy outcomes in asymptomatic women with inherited thrombophilias,” American Journal of Obstetrics and Gynecology, vol. 200, no. 3, pp. 281.e1–281.e5, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. P. W. Howie, “Anticoagulants in pregnancy,” Clinical Obstetrics and Gynecology, vol. 13, no. 2, pp. 349–363, 1986. View at Google Scholar
  16. M. A. Rodger, M. Paidas, M. Claire et al., “Inherited thrombophilia and pregnancy complications revisited,” Obstetrics and Gynecology, vol. 112, no. 2, part 1, pp. 320–324, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Middeldorp, “Thrombophilia and pregnancy complications: cause or association?” Journal of Thrombosis and Haemostasis, vol. 5, no. 1, pp. 276–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. H. James, “Venous thromboembolism in pregnancy,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 3, pp. 326–331, 2009. View at Publisher · View at Google Scholar
  19. M. Villani, G. L. Tiscia, M. Margaglione et al., “Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying common inherited thombophilias,” Journal of Thrombosis and Haemostasis, vol. 10, no. 2, pp. 223–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. S. Arkel and D.-H. W. Ku, “Thrombophilia and pregnancy: review of the literature and some original data,” Clinical and Applied Thrombosis/Hemostasis, vol. 7, no. 4, pp. 259–268, 2001. View at Google Scholar · View at Scopus
  21. M. J. Kupferminc, “Thrombophilia and pregnancy,” Reproductive Biology and Endocrinology, vol. 1, article 111, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Tanner, R. Levine, and S. J. Kittner, “Epidemiology of antiphospholipid antibodies and vascular disease,” in Clinical Approach to Antiphospholipid Antibodies, S. R. Levine and R. L. Brey, Eds., p. 18, Butterworth Heinemann, Boston, Mass, USA, 2000. View at Google Scholar
  23. F. C. Battaglia and L. O. Lubchenco, “A practical classification of newborn infants by weight and gestational age,” The Journal of Pediatrics, vol. 71, no. 2, pp. 159–163, 1967. View at Google Scholar · View at Scopus
  24. J. G. Ray and W. S. Chan, “Deep vein thrombosis during pregnancy and the puerperium: a meta- analysis of the period of risk and the leg of presentation,” Obstetrical and Gynecological Survey, vol. 54, no. 4, pp. 265–271, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. S. Refuerzo, J. L. Hechtman, M. E. Redman, and J. E. Whitty, “Venous thromboembolism during pregnancy: clinical suspicion warrants evaluation,” Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 48, no. 10, pp. 767–770, 2003. View at Google Scholar · View at Scopus
  26. O. Wu, L. Robertson, S. Twaddle et al., “Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study,” Health Technology Assessment, vol. 10, no. 11, pp. 1–110, 2006. View at Google Scholar
  27. R. Cantwell, T. Clutton-Brock, G. Cooper et al., “Saving mothers' lives: reviewing maternal deaths to make motherhood safer: 2006–2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom,” BJOG, vol. 118, supplement 1, pp. 1–203, 2011. View at Google Scholar · View at Scopus