High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Figure 3

Cumulative percentage of tramadol hydrochloride released in vitro from once-daily SD HASCA formulations, compressed using a single-stroke press machine (SSP), and once-daily commercial formulations (■: 700-mg tablets with 100 mg of drug, ●: 800-mg tablets with 200 mg of drug, ▲: Tridural 100 mg, and ◆: Tridural 200 mg). Tests were performed with the tablets placed inside a cage. 𝑓₂ values: 70.66 between 700-mg tablets with 100 mg and Tridural 100 mg, 79.80 between 800-mg tablets with 200 mg and Tridural 200 mg, 93.14 between 700-mg tablets with 100 mg, and 800-mg tablets with 200 mg.