High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Figure 4

Cumulative percentage of tramadol hydrochloride released in vitro from twice-daily SD HASCA formulations, compressed with the single-stroke press machine, and twice-daily commercial formulations (◆: 450-mg tablets with 100 mg of drug, ■: 500-mg tablets with 200 mg of drug, ▲: Topalgic LP 100 mg, and ●: Topalgic LP 200 mg). Tests were performed with the tablets placed inside a cage. 𝑓₂ values: 54.52 between 450-mg tablets with 100 mg and Topalgic LP 100 mg, 52.36 between 500-mg tablets with 200 mg of drug and Topalgic LP 200 mg, and 88.01 between 450-mg tablets with 100 mg and 500-mg tablets with 200 mg of drug.