High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Table 4

Time to release 50% and 90% of tramadol hydrochloride [T50%, T90%] for SD HASCA tablets compressed between 1 and 2.5 tons/cm² and similarity factors (𝑓₂) between tablets weighting 700-mg tablets with 100 mg of tramadol hydrochloride, compressed with a 30-tons manual HP at different CFs.

CF (tons/cm^2)	[T50%, T90%] (hours)	𝑓2 versus 2.5 tons/cm^2
1	[3.90, 14.25]	90
1.5	[4.10, 14.50]	89
2	[4.25, 15.40]	84
2.5	[4.00, 14.40]