High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

Table 5

Time to release 50% and 90% (hours) of tramadol hydrochloride [T50%, T90%] from twice-daily and once-daily SD HASCA tablets with 100 mg and 200 mg of drug, compressed using a 30-tons manual hydraulic press at 2.5 tons/cm² (HP) or a single-stroke press (SSP).

Frequency of administration	Formulation
	100 mg of drug (HP)	100 mg of drug (SSP)	200 mg of drug (HP)	200 mg of drug (SSP)
Twice-daily	[1.90, 6.40]	[3.00, 10.70]	[1.90, 6.70]	[3.00, 10.25]
Once-daily	[4.00, 14.40]	[5.20, 20.40]	[4.10, 16.40]	[5.20, 19.10]