Table of Contents
ISRN Medicinal Chemistry
Volume 2014 (2014), Article ID 393102, 6 pages
http://dx.doi.org/10.1155/2014/393102
Research Article

Synthesis and Antibacterial Screening of Some 1-Aroyl-3-aryl Thiourea Derivatives

School of Pharmacy, Devi Ahilya University, Ring Road, Indore 452017, India

Received 15 October 2013; Accepted 17 December 2013; Published 29 January 2014

Academic Editors: A. Contini, F. A. Pasha, and Y. S. Prabhakar

Copyright © 2014 Love Kumar Soni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of 1-aroyl-3-aryl thioureas derivatives were synthesized and evaluated for antibacterial activity. The results indicated that the compounds possessed higher activity against gram-negative bacteria than gram-positive bacteria. Amongst all these compounds, C18 (89.4%) exhibited the greatest antibacterial activity against gram-negative bacteria while C5 (85.6%) displayed maximum antibacterial activity against gram-positive bacteria. Preliminary study of the structure-activity relationship revealed that an electronic factor on aryl rings had a great effect on the antibacterial activity of these compounds.