Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 407142, 7 pages
http://dx.doi.org/10.1155/2014/407142
Clinical Study

Effect of 82% Lactic Acid in Treatment of Melasma

1Department of Pharmacology, Rohilkhand Medical College and Hospital, Bareilly 243006, India
2Department of Skin and Venereology, Rohilkhand Medical College and Hospital, Bareilly 243006, India
3Department of Physiology, Rohilkhand Medical College and Hospital, Bareilly 243006, India
4Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly 243202, India

Received 1 April 2014; Revised 23 May 2014; Accepted 24 May 2014; Published 17 July 2014

Academic Editor: Faiyaz Shakeel

Copyright © 2014 Rashmi Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Melasma is an acquired, chronic, and symmetrical hypermelanosis, characterized by brown patches of variable darkness on sun exposed areas of body. There are numerous modalities of treatment currently in use for this disease, of which the chemical peeling is very commonly used. Therefore, the present work was done to see the effect of 82% lactic acid peel in the treatment of melasma. A total number of 20 patients of either sex attending the OPD of dermatology department with clinically evident melasma were included in the study. 82% Lactic acid peel was applied on the face for 12 weeks in each patient. Patients were evaluated clinically and photographically at various intervals and in follow-up till 24 weeks. Assessment of patient satisfaction and side effects were also noted. All the subjects completed the study. Application of this peel for 12 weeks significantly decreased the melasma area severity index score and also melasma severity scale score. Patient and physician analogue scales also showed the improvement by the treatment. Regarding the adverse effects, burning sensation was the only side effect noted in our study. In conclusion, 82% lactic acid peel is well tolerated and can be used for the treatment of melasma.