Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 407272, 8 pages
Research Article

Stability Analysis of an Improved HBV Model with CTL Immune Response

1Department of Mathematics and Computer Science, Faculty of Sciences Ben M’sik, Hassan II University, P.O. Box 7955, Sidi Othman, Casablanca, Morocco
2Centre Régional des Métiers de l’Education et de la Formation (CRMEF), Derb Ghalef, 20340 Casablanca, Morocco

Received 9 June 2014; Accepted 30 August 2014; Published 29 October 2014

Academic Editor: San-Lin You

Copyright © 2014 Mostafa Khabouze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To better understand the dynamics of the hepatitis B virus (HBV) infection, we introduce an improved HBV model with standard incidence function, cytotoxic T lymphocytes (CTL) immune response, and take into account the effect of the export of precursor CTL cells from the thymus and the role of cytolytic and noncytolytic mechanisms. The local stability of the disease-free equilibrium and the chronic infection equilibrium is obtained via characteristic equations. Furthermore, the global stability of both equilibria is established by using two techniques, the direct Lyapunov method for the disease-free equilibrium and the geometrical approach for the chronic infection equilibrium.