Table of Contents
ISRN Medicinal Chemistry
Volume 2014, Article ID 410716, 7 pages
http://dx.doi.org/10.1155/2014/410716
Research Article

Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells

1Organic Chemistry Division, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India
2Chemical Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India

Received 28 October 2013; Accepted 13 February 2014; Published 22 April 2014

Academic Editors: T. H. Al-Tel, F. Dufrasne, and C. Gong

Copyright © 2014 Periasamy Selvakumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of pyridopyridazin-3(2H)-one derivatives was synthesized in two facile steps. Mannich-type three-component condensation afforded the 2,6-diaryl piperidin-4-one derivatives, which underwent intramolecular cyclization in the presence of hydrazine or phenylhydrazine to yield the corresponding pyridopyridazin-3(2H)-one derivatives. All the derivatives of pyridopyridazin-3(2H)-one, except 3e and 3f, showed moderate activity against human breast adenocarcinoma (MCF-7) cells. The higher degree of inhibition of MCF-7 cell proliferation shown by 2a2f indicates the significance of the amide proton in pyridopyridazin-3(2H)-one derivatives.