Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells

<table>Synthesis of pyridopyridazin-3(2H)-one derivatives. Reagents and conditions: (i) N<sub>2</sub>H<sub>4</sub>·H<sub>2</sub>O, ethanol, reflux, 17 h; (ii) PhNHNH<sub>2</sub>, dry toluene, TFA (20 mol%), reflux, 2 days.</table>

International Scholarly Research Notices

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Scheme 2

Scheme 2: Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells 