Table of Contents
ISRN Oncology
Volume 2014, Article ID 412527, 7 pages
http://dx.doi.org/10.1155/2014/412527
Review Article

Primary Synovial Sarcomas of the Mediastinum: A Systematic Review and Pooled Analysis of the Published Literature

1Department of Medical Oncology, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, Amman 11941, Jordan
2Department of Radiation Oncology, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, Amman 11941, Jordan

Received 24 September 2013; Accepted 10 November 2013; Published 20 January 2014

Academic Editors: C. Damodaran and K. Van Golen

Copyright © 2014 Samer Salah and Ahmed Salem. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this systematic review is to attempt to provide a descriptive analysis for cases of synovial sarcoma (SS) arising in the mediastinum and to analyze prognostic factors. Methods. We performed PubMed database search in July 2013. Twenty-two studies, which included 40 patients, form the basis of this review. Demographic and disease-related factors were analyzed for possible influence on survival. Findings were compared with extremity SS studies reported in literature. Results. Sixteen cases (40%) presented with locally advanced unresectable disease, 2 (5%) with metastatic disease, and 22 (55%) with localized resectable disease. Median tumor size was 11 cm (range: 5–20 cm). Thirty patients were assessable for survival and had a 5-year OS of 36%. Completeness of resection was the only factor associated with significant improvement in OS (5-year survival of 63% and 0% in favor of complete resection, ). Conclusion. Mediastinal SS is associated with poor prognosis as more cases are diagnosed at an advanced stage and with larger tumor size compared to extremity SS. Complete surgical resection is the only identified factor associated with better prognosis and may result in survival outcomes that are comparable with those for localized SS of the extremity.