Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 412704, 6 pages
http://dx.doi.org/10.1155/2014/412704
Research Article

Determination of Magnesium Valproate and Its Process Related Impurities by Ultraperformance Liquid Chromatography

National Facility for Drug Discovery through NCEs Development & Instrumentation Support to SMPEs, Department of Chemistry, Saurashtra University, Rajkot, Gujarat 360005, India

Received 23 March 2014; Revised 27 April 2014; Accepted 28 April 2014; Published 14 July 2014

Academic Editor: Luigi Janiri

Copyright © 2014 Rakshit Thakkar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. K. Borowicz, Z. Kimber-Trojnar, N. Ratnaraj, P. N. Patsalos, J. J. Luszczki, and S. J. Czuczwar, “Isobolographic analysis of interactions between losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model,” European Neuropsychopharmacology, vol. 17, no. 2, pp. 94–101, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Gobbi and L. Janiri, “Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex,” Psychopharmacology, vol. 185, no. 2, pp. 255–262, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. K. K. Borowicz, B. Piskorska, J. Łuszczki, and S. J. Czuczwar, “Influence of SIB 1893, a selective mGluR5 receptor antagonists, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy,” Polish Journal of Pharmacology, vol. 55, no. 5, pp. 735–740, 2003. View at Google Scholar · View at Scopus
  4. R. Canger and L. Guidolin, “Clinical efficacy and tolerability of magnesium valproate as monotherapy in patients with generalised or partial epilepsy: a nonblinded study of 320 patients,” Clinical Drug Investigation, vol. 20, no. 4, pp. 215–221, 2000. View at Google Scholar · View at Scopus
  5. M. Onofrj, U. Colangelo, G. Malatesta, and M. Di Giovanni, “Comparative study between sodium valproate and magnesium valproate in the treatment of patients with epileptic seizures,” Rivista di Neurologia, vol. 58, no. 6, pp. 223–230, 1988. View at Google Scholar · View at Scopus
  6. M. Lalic, J. Cvejic, J. Popovic et al., “Lamotrigine and valproate pharmacokinetics interactions in epileptic patients,” European Journal of Drug Metabolism and Pharmacokinetics, vol. 34, no. 2, pp. 93–99, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Hao, C. Yan, and Y. Liu, “Determination of magnesium and sodium valproate in serum by high performance liquid chromatography after precolumn derivatization,” Yaowu Fenxi Zazhi, vol. 17, pp. 172–174, 1997. View at Google Scholar
  8. A. Balbi, E. Sottofattori, M. Mazzei, and W. G. Sannita, “Study of bioequivalence of magnesium and sodium valproates,” Journal of Pharmaceutical and Biomedical Analysis, vol. 9, no. 4, pp. 317–321, 1991. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Hu, S. Huang, and B. Xiao, “Determination of magnesium valproate in serum by gas chromatography,” Se Pu, vol. 5, pp. 362–364, 1987. View at Google Scholar
  10. W. Czarnecki and B. Hałczyńska, “Colorimetric determination of valproic acid and its salts,” Acta Poloniae Pharmaceutica: Drug Research, vol. 56, no. 5, pp. 353–355, 1999. View at Google Scholar · View at Scopus
  11. M. A. Ambasana, H. O. Kaila, R. S. Thakkar, H. T. Saravaia, and A. K. Shah, “Validation of an analytical method for assay of magnesium valproate by gas chromatography,” International Journal of ChemTech Research, vol. 3, no. 1, pp. 342–347, 2011. View at Google Scholar · View at Scopus
  12. X. Zhan and M. Xu, “Determination of sodium valproate in human serum by HPLC,” Zhongguo Yaoye, vol. 18, pp. 25–26, 2009. View at Google Scholar
  13. Y. X. Lin and H. C. Su, “RP-HPLC determination of valproate concentration in serum,” Zhongguo Jiceng Yiyao, vol. 14, pp. 1300–1301, 2007. View at Google Scholar
  14. C. A. Lau-Cam and R. W. Roos, “HPLC method with precolumn phenacylation for the assay of Valproic acid and its salts in pharmaceutical dosage forms,” Journal of Liquid Chromatography & Related Technologies, vol. 20, pp. 2075–2087, 1997. View at Google Scholar
  15. M. Nakajima, A. Sato, and K. Shimada, “Determination of serum valproate by high-performance liquid chromatography using fluorescence labeling with 9-aminophenanthrene,” Analytical Sciences, vol. 4, no. 4, pp. 385–388, 1988. View at Publisher · View at Google Scholar
  16. T. Maeda, F. Miyagawa, M. Nakamura, and M. Saito, “Determination of antiepileptic drugs by high performance liquid chromatography,” Sei Marianna Ika Daigaku Zasshi, vol. 10, pp. 153–161, 1982. View at Google Scholar
  17. Y. Zhong, Z. Jiao, and Y. Yu, “Simultaneous determination of mycophenolic acid and valproic acid based on derivatization by high-performance liquid chromatography with fluorescence detection,” Biomedical Chromatography, vol. 20, no. 4, pp. 319–326, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Hara, M. Kamura, K. Inoue, M. Fukuzawa, N. Ono, and T. Kuroda, “Determination of valproic acid in human serum by high-performance liquid chromatography with fluorescence detection,” Biological and Pharmaceutical Bulletin, vol. 22, no. 9, pp. 975–977, 1999. View at Google Scholar · View at Scopus
  19. E. Bousquet, V. Cavrini, R. Gatti, and A. Spadaro, “Determination of valproic acid salts in pharmaceutical preparations by high performance liquid chromatography with coulometric electrochemical detection,” Journal of Liquid Chromatography and Related Technologies, vol. 21, no. 18, pp. 2873–2886, 1998. View at Google Scholar · View at Scopus
  20. H. Liu, L. J. Forman, J. Montoya, C. Eggers, C. Barham, and M. Delgado, “Determination of valproic acid by high-performance liquid chromatography with photodiode-array and fluorescence detection,” Journal of Chromatography: Biomedical Applications, vol. 576, no. 1, pp. 163–169, 1992. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Kondo, M. Nakamura, R. Nishioka, and S. Kawai, “Direct method for determination of Valproic acid in serum by high performance liquid chromatography,” Analytical Sciences, vol. 1, pp. 385–387, 1985. View at Publisher · View at Google Scholar
  22. ICH-Q2(R1), International Conference on Harmonization validation of analytical procedures: text and methodology, 2005.