Research Article
Determination of Magnesium Valproate and Its Process Related Impurities by Ultraperformance Liquid Chromatography
Table 2
Summary of validation study.
| Validation experiment | PA | 2-EPA | 2-1-MEPA | VA | MgVA |
| Specificity | No interference | No interference | No interference | No interference | No interference | LOQ (g/mL) | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | LOD (g/mL) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | Linearity | | | | | |
(I) Correlation coefficient | 0.999 | 0.998 | 0.999 | 0.997 | 0.998 |
(II) Regression equation | | | | | | Method precision () | %RSD = 0.2 | %RSD = 0.2 | %RSD = 0.2 | %RSD = 1.2 | %RSD = 0.1 | Int. precision () | %RSD = 1.2 | %RSD = 0.8 | %RSD = 0.8 | %RSD = 1.8 | %RSD = 0.7 | Accuracy (% recovery) | 99–101 | 98–100 | 99-100 | 98–102 | 99-100 | Robustness | No significant change | No significant change | No significant change | No significant change | No significant change |
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