Risks and Benefits of Thrombolytic, Antiplatelet, and Anticoagulant Therapies for ST Segment Elevation Myocardial Infarction: Systematic Review

Table 3

Multivariate regression with binomial response for death, acute myocardial infarction and major bleeding, with number of drugs (N drugs) and primary angioplasty (PA) as independent variables.

Outcome	Death			Major bleeding			AMI
Parameter	β-Coefficient	Standard error	P	β-Coefficient	Standard error	P	β-Coefficient	Standard error	P
N drugs	−0.233	0.054	<0.001*	0.405	0.154	0.012*	−0.039	0.064	0.550
PA	−1.605	0.409	<0.001*	2.251	1.049	0.039*	−0.629	0.478	0.197
Interaction1	0.294^a	0.120	0.019*	−0.355^a	0.308	0.258	−0.162^a	0.142	0.262
Latent variable	0.079	0.022	0.001*	0.670	0.176	<0.001*	0.111	0.033	0.002*
	Odds	IC 95%		Odds	IC 95%		Odds	IC 95%
PA −	0,791	0,704–0,879		1,499	1,030–1,968		0,961	0,836–1,088
PA +	1,062	0,831–1,293		1,051	0,480–1,622		1,131	0,840–1,422

Latent variable inserted in the model to minimize the variability effect between studies. Interactions tested in models: ^adrugs: PA; ^bPA: bleeding and ^cPA: death, (without statistical significance). IC 95%: reliability interval 95%.
* P < 0.05.