Lung Volume Reduction Surgery for Emphysema Treatment: State-of-the-Art and Perspectives

Table 4

Results of randomized studies on LVRS*.

First; author	Year	Time of assessment; (months)	FEV1	RV	6MWT	PaO2	DLCO	Quality; of life
Criner [14]	1999	3	31	−24.5	9.4	—	16.6	—
Geddes [15]	2000	6	23	−28	29	−4.1	—	41 (SF-36)
Pompeo [16]	2000	6	53	−25	24	7	—	—
Goldstein [17]	2003	6	37.5	−16	4.1	—	—	—
Hillerdal [18]	2005	6	24	−25	35	5.2	—	32 (SGRQ)
								111 (SF-36, PF)
Miller [19]	2006	6	27.5	−25	13	—	15	—
Pompeo [20]	2012	6	36	−17.4	27	4.4	—	75.8 (SF-36, PF)
			35^§	−20.8^§	31^§	5.8^§	—	110 (SF-36, PF)^§

∗Surgical arms results of studies in which % change from baseline values was computable are included. LVRS: lung volume reduction surgery; FEV₁: forced expiratory volume in one second; RV: residual volume; 6MWT: 6-minute walking test; PaO₂: arterial oxygen pressure; DLCO: diffusion capacity for carbon monoxide; SF-36: short form 36-items questionnaire; SGRQ: St.George questionnaire; PF: physical functioning domain score. §Results of awake nonresectional LVRS.