Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones

Table 2

Inhibitory zone (diameter) (in mm) of synthesized compounds against tested fungal strains by disc diffusion method.

Compound	Candida albicans	Saccharomyces cerevisiae	Aspergillus flavus	Aspergillus niger
12a	22	16	07	09
12b	16	09	05	03
12c	13	06	04	03
12d	28	19	11	13
12e	24	15	14	10
12f	16	12	05	04
12g	22	16	08	10
12h	24	16	09	11
Fluconazole	24	19	10	08

Synthesized compound taken is 10 L of 25 mg/1 mL and fluconazole (25 g per disc) is the positive reference standard antifungal disc.