Table of Contents
ISRN Dentistry
Volume 2014, Article ID 479187, 4 pages
Research Article

Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study

1Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, India
2Department of Oral Pathology & Microbiology, Mahe Institute of Dental Sciences, Palloor, Mahe, Puducherry, India
3Department of Oral Pathology & Microbiology, Saraswati Dental College, Lucknow, India
4Department of Oral & Maxillofacial Surgery, King George's Medical University, Lucknow, India
5Department of Oral Pathology & Microbiology, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India
6Department of Oral Pathology & Microbiology, Babu Banarsi Das College of Dental Sciences, Lucknow, India
7Department of Pedodontics, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India

Received 5 December 2013; Accepted 25 December 2013; Published 30 April 2014

Academic Editors: M. Okura and D. Wray

Copyright © 2014 Fahad Mansoor Samadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.