Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 495927, 6 pages
Research Article

Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Evaluation of Copolyester Bearing 4-Arylidene Curcumin in the Main Chain

Postgraduate and Research Department of Chemistry, Pachaiyappa’s College, Chennai 600 030, India

Received 11 June 2014; Revised 2 August 2014; Accepted 20 August 2014; Published 29 October 2014

Academic Editor: Hongwei Duan

Copyright © 2014 Narendran Kandaswamy and Nanthini Raveendiran. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of random copolyester bearing 4-arylidene curcumin M1 in the polymer backbone was prepared by solution polycondensation method. The influence of copolyester bearing 4-arylidene curcumin M1 unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and studied in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.19 dL/g and 1.38, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was investigated.