Table of Contents
ISRN Cell Biology
Volume 2014 (2014), Article ID 526075, 10 pages
http://dx.doi.org/10.1155/2014/526075
Research Article

Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression

1Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia
2King Fahd Medical Research Centre, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia
3Faculty of Life and Physical Sciences, The University of Western Australia (M011), 35 Stirling Highway, Crawley, WA 6009, Australia

Received 9 June 2013; Accepted 7 July 2013; Published 22 April 2014

Academic Editors: D. Arnoult, A. Bruzzaniti, and C. Reynaud

Copyright © 2014 Kothandaraman Narasimhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table SIA. miRNAs differentially regulated in colon adenoma tissues. We also describe the biomarker functions associated with each specifc miRNAs which is correlated with their expression. Ω - Tumour suppressor, # - oncogene, †- oncomirs, * mature miRNA sequence from the opposite arm of the precursor.

Table SIB. Summary of miRNAs differentially regulated in colon carcinoma tissues. We also describe the biomarker functions associated with each specifc miRNAs which is correlated with their expression. Ω - Tumour suppressor, # - oncogene, †- oncomirs, * mature miRNA sequence from the opposite arm of the precursor.

Table SIIA. Molecular and cellular function associated with miRNAs involved in colon adenoma tissues.

Table SIIB. Molecular and cellular function associated with miRNAs involved with colon carcinoma tissues.

Table SIIC. Our analysis on miRNAs showed a broader impact of miRNAs in various types of diseases and disorders associated with human beings which is consistent with the nature of action of miRNAs in general. These miRNAs though found associated with colon adenoma and colon carcinoma were found to affect a wide spectrum of diseases as listed below in the table SIIC.

Table SIIIA. Genes and miRNAs most overrepresented in networks associated with colon adenoma. 5 networks were identified to be associated with colon carcinoma. Those genes and miRNAs that were represented 2 or more times were shown in the table.

Table SIIIB. Genes and miRNAs most overrepresented in networks associated with colon carcinoma. 13 networks were identified to be associated with colon carcinoma. Those genes and miRNAs that were represented 10 or more times were shown in the table.

  1. Supplementary Material