Table of Contents
ISRN Otolaryngology
Volume 2014, Article ID 529395, 6 pages
Research Article

Oral Tongue Squamous Cell Carcinoma in Young Women: A Matched Comparison—Do Outcomes Justify Treatment Intensity?

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 2233 Post Street, San Francisco, CA 94115, USA

Received 29 December 2013; Accepted 3 February 2014; Published 10 March 2014

Academic Editors: F. Esteban and C. Suárez

Copyright © 2014 Ryan P. Goepfert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The incidence of oral tongue squamous cell carcinoma (OTSCC) in young women is increasing with uncertain outcomes compared to traditional patients. Published outcomes data are at odds in this cohort of young women. Methods. Retrospective analysis comparing demographic, clinicopathologic, and outcomes data of women OTSCC patients younger than 45 years old matched 1 : 2 by stage with men both younger and older than 45 and women older than 45. Results. No disease-free or overall survival differences were found between cohorts. Young women were significantly more likely to receive radiation therapy, particularly in stage I disease, even when controlling for common pathologic indications. Conclusions. OTSCC in young women was not associated with worse outcomes compared to a matched cohort of other patients. Increased frequency of radiation treatment for this cohort may not be justified.