An Improved Experimental Model of Hemorrhoids in Rats: Evaluation of Antihemorrhoidal Activity of an Herbal Formulation
Effect of Pilex on histology of rectoanal tissue in a rat model of croton oil-induced hemorrhoids. Recto anal sections of rats: (a) section showing normal appearance and architecture in normal control group; (b) marked to severe inflammation, congestion, haemorrhage, dilatation of blood vessels, degeneration, and necrosis can be observed in the section of untreated positive control group; (c) section of rat treated with Pilex ointment (200 mg/rat) showing mild inflammation, marked congestion, degeneration, and necrosis; (d) and (e) sections of rat treated with Pilex granules (200 & 400 mg/kg p.o.) showing minimal inflammation, congestion, haemorrhage, dilatation of blood vessels, degeneration, and necrosis; (f) and (g) sections of rat treated with Pilex granules (200 & 400 mg/kg) along with Pilex ointment showing near normal architecture (H&E × 200).
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