Downregulation of RelA (p65) by Rapamycin Inhibits Murine Adipocyte Differentiation and Reduces Fat Mass of C57BL/6J Mice despite High Fat Diet
Figure 1
Rapamycin (RAPA) inhibited adipogenesis of ADSCs in vitro. (a) Resting cells in control media (CM) showed a differentiated contractile phenotype characterized by an irregular shape. (b) Incubation with adipogenic differentiation medium for two weeks induced adipocyte differentiation. Oil Red-O staining of differentiated muADSC without rapamycin treatment show significant numbers of cells and robust phenotype. (c) Differentiating muADSC cells treated with rapamycin and stained with Oil Red-O demonstrated visibly fewer cells and a smaller phenotype.
