Downregulation of RelA (p65) by Rapamycin Inhibits Murine Adipocyte Differentiation and Reduces Fat Mass of C57BL/6J Mice despite High Fat Diet

Table 2

Effects of rapamycin on fat weights in C57BL/6J mice fed with D (10% fat diet) or HFD (40% fat diet), with or without rapamycin (R). Data are expressed as mean ± SEM. 𝑛=10 mice for each group. 𝑃<0.001. Sub: subcutaneous; OM: omental.

	D	DR	HD	HDR
Absolute weight (g)
Sub	1.18±0.054	0.34±0.022^∗∗	1.87±0.068	0.66±0.051^∗∗
OM	1.45±0.089	0.24±0.029^∗∗	1.88±0.109	0.55±0.043^∗∗
Percent of body weight (%)
Sub	3.26±0.102	1.25±0.064^∗∗	3.83±0.106	2.02±0.146^∗∗
OM	3.69±0.240	0.87±0.091^∗∗	3.85±0.177	1.68±0.123^∗∗

Data are presented as means ± SEM. The two-tailed 𝑃 value is <0.0001 (**), extremely significant.