Table of Contents
ISRN Obesity
Volume 2014 (2014), Article ID 545804, 7 pages
http://dx.doi.org/10.1155/2014/545804
Research Article

Carotid Intima Media Thickness Is Independently Associated with Male Gender, Middle Age, and IGF-1 in Metabolically Healthy Obese Individuals

1Internal Medicine Department, Mansoura Specialized Medical Hospital, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
2Radiology Department, Mansoura University Hospital, Faculty of Medicine, Mansoura University, Egypt
3Clinical Pathology Department, Mansoura University Hospital, Faculty of Medicine, Mansoura University, Egypt

Received 12 July 2013; Accepted 16 September 2013; Published 28 January 2014

Academic Editors: K.-C. Huang, N. M. Lalic, and D. Malkova

Copyright © 2014 Hala Abd El-Hafez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. D. Karelis, M. Brochu, and R. Rabasa-Lhoret, “Can we identify metabolically healthy but obese individuals (MHO)?” Diabetes and Metabolism, vol. 30, no. 6, pp. 569–572, 2004. View at Google Scholar · View at Scopus
  2. M. Brochu, A. Tchernof, I. J. Dionne et al., “What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 1020–1025, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. R. P. Wildman, P. Muntner, K. Reynolds et al., “The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004),” Archives of Internal Medicine, vol. 168, no. 15, pp. 1617–1624, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. D. Karelis, D. H. St-Pierre, F. Conus, R. Rabasa-Lhoret, and E. T. Poehlman, “Metabolic and body composition factors in subgroups of obesity: what do we know?” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2569–2575, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. J. B. Meigs, P. W. F. Wilson, C. S. Fox et al., “Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 2906–2912, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. D. H. O’Learly and J. F. Polak, “Intima media thickness: a tool for atherosclerosis imaging and event prediction,” American Journal of Cardiology, vol. 90, no. 10, pp. 18–20, 2002. View at Publisher · View at Google Scholar
  7. M. W. Lorenz, H. S. Markus, M. L. Bots, M. Rosvall, and M. Sitzer, “Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis,” Circulation, vol. 115, no. 4, pp. 459–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Sinning, P. S. Wild, F. M. O. Echevarria et al., “Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart study),” American Journal of Cardiology, vol. 107, no. 12, pp. 1841–1847, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. T.-Y. Tan, C.-H. Lu, T.-K. Lin, C.-W. Liou, Y.-C. Chuang, and U. Schminke, “Factors associated with gender difference in the intima-media thickness of the common carotid artery,” Clinical Radiology, vol. 64, no. 11, pp. 1097–1103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Lo, S. E. Dolan, J. R. Kanter et al., “Effects of obesity, body compositionand adiponectin on carotid intima-media thickness in healthy women,” Journal of Clinical Endocrinology and Metabolism, vol. 9, no. 5, pp. 11677–11682, 2006. View at Google Scholar
  11. M. A. Espeland, R. Tang, J. G. Terry, D. H. Davis, M. Mercuri, and J. R. Crouse III, “Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery,” Stroke, vol. 30, no. 5, pp. 1047–1055, 1999. View at Google Scholar · View at Scopus
  12. C. S. Lam, M. H. Chen, S. M. Lacey et al., “Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, pp. 1479–1484, 2010. View at Publisher · View at Google Scholar
  13. J. M. Faupel-Badger, D. Berrigan, R. Ballard-Barbash, and N. Potischman, “Anthropometric correlates of insulin-like growth factor 1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels by race/ethnicity and gender,” Annals of Epidemiology, vol. 19, no. 12, pp. 841–849, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Kawashi, N. Takeda, A. Sasaki et al., “Circulating insulin-like growth factor binding protein-3 is associated with early carotid atherosclerosis.,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, pp. 617–621, 2005. View at Publisher · View at Google Scholar
  15. E. Spilcke-Liss, N. Friedrich, M. Dörr et al., “Serum insulin-like growth factor I and its binding protein 3 in their relation to intima-media thickness: results of the Study of Health in Pomerania (SHIP),” Clinical Endocrinology, vol. 75, no. 1, pp. 70–75, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Marini, E. Succurro, S. Frontoni et al., “Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women,” Diabetes Care, vol. 30, no. 8, pp. 2145–2147, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Hietaniemi, S. M. Pöykkö, O. Ukkola, M. Päivänsalo, and Y. A. Kesäniemi, “IGF-I concentrations are positively associated with carotid artery atherosclerosis in women,” Annals of Medicine, vol. 37, no. 5, pp. 373–382, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. U. I. Khan, D. Wang, R. C. Thurston et al., “Burden of subclinical cardiovascular disease in “metabolically benign” and “at-risk” overweight and obese women: the Study of Women's Health Across the Nation (SWAN),” Atherosclerosis, vol. 217, no. 1, pp. 179–186, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. S. M. Grundy, J. I. Cleeman, S. R. Daniels et al., “Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement,” Circulation, vol. 112, no. 17, pp. 2735–2752, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. D. Karelis and R. Rabasa-Lhoret, “Inclusion of C-reactive protein in the identification of Metabolically Healthy but Obese (MHO) individuals,” Diabetes and Metabolism, vol. 34, no. 2, pp. 183–184, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Google Scholar · View at Scopus
  22. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  23. J. Ärnlöv, E. Ingelsson, J. Sundström, and L. Lind, “Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men,” Circulation, vol. 121, no. 2, pp. 230–236, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Park, S. H. Kim, G. Y. Cho et al., “Obesity phenotype and cardiovascular changes,” Journal of Hypertension, vol. 29, no. 9, pp. 1765–1772, 2011. View at Publisher · View at Google Scholar
  25. E. M. Urbina, T. R. Kimball, C. E. McCoy, P. R. Khoury, S. R. Daniels, and L. M. Dolan, “Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function,” Circulation, vol. 119, no. 22, pp. 2913–2919, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Kozakova, C. Palombo, M. Paterni et al., “Body composition and common carotid artery remodeling in a healthy population,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 9, pp. 3325–3332, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Simon, J. Levenson, J. Bouthier, and B. Maarek, “Haemodynamic basis of early modifications of the large arteries in borderline hypertension,” Journal of Hypertension, vol. 5, no. 2, pp. 179–184, 1987. View at Google Scholar · View at Scopus
  28. T. A. Lakka, H.-M. Lakka, R. Salonen, G. A. Kaplan, and J. T. Salonen, “Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men,” Atherosclerosis, vol. 154, no. 2, pp. 497–504, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. J. I. Recio-Rodriguez, M. A. Gomez-Marcos, M. C. Patino-Alonso, C. Agudo-Conde, E. Rodriguez-Sanchez, and L. Garcia-Ortiz, “Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive,” BMC Cardiovascular Disorders, vol. 12, article 3, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. de Michele, S. Panico, A. Iannuzzi et al., “Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women,” Stroke, vol. 33, no. 12, pp. 2923–2928, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. J. J. Cao, A. M. Arnold, T. A. Manolio et al., “Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health study,” Circulation, vol. 116, no. 1, pp. 32–38, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. L. G. Spagnoli, A. Mauriello, A. Orlandi, G. Sangiorgi, and E. Bonanno, “Age-related changes affecting atherosclerotic risk. Potential for pharmacological intervention,” Drugs and Aging, vol. 8, no. 4, pp. 275–298, 1996. View at Google Scholar · View at Scopus
  33. A. Tosetto, P. Prati, C. Baracchini, R. Manara, and F. Rodeghiero, “Age-adjusted reference limits for carotid intima-media thickness as better indicator of vascular risk: population-based estimates from the VITA project,” Journal of Thrombosis and Haemostasis, vol. 3, no. 6, pp. 1224–1230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Juul, T. Scheike, M. Davidsen, J. Gyllenborg, and T. Jørgensen, “Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study,” Circulation, vol. 106, no. 8, pp. 939–944, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. E. E. Calle and R. Kaaks, “Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms,” Nature Reviews Cancer, vol. 4, no. 8, pp. 579–591, 2004. View at Google Scholar · View at Scopus
  36. D. V. Soares, L. D. Spina, R. R. de Lima Oliveira Brasil et al., “Carotid artery intima-media thickness and lipid profile in adults with growth hormone deficiency after long-term growth hormone replacement,” Metabolism, vol. 54, no. 3, pp. 321–329, 2005. View at Publisher · View at Google Scholar
  37. A. Colao, P. Marzullo, and G. Lombardi, “Effect of a six-month treatment with lanreotide on cardiovascular risk factors and arterial intima-media thickness in patients with acromegaly,” European Journal of Endocrinology, vol. 146, no. 3, pp. 303–309, 2002. View at Publisher · View at Google Scholar
  38. H. J. Arnqvist, “The role of IGF-system in vascular insulin resistance,” Hormone and Metabolic Research, vol. 40, no. 9, pp. 588–592, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Higashi, S. Sukhanov, A. Anwar, S.-Y. Shai, and P. Delafontaine, “IGF-1, oxidative stress and atheroprotection,” Trends in Endocrinology and Metabolism, vol. 21, no. 4, pp. 245–254, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Sukhanov, Y. Higashi, S.-Y. Shai et al., “IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 12, pp. 2684–2690, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Perticone, A. Sciacqua, M. Perticone et al., “Low-plasma insulin-like growth factor-I levels are associated with impaired endothelium-dependent vasodilatation in a cohort of untreated, hypertensive caucasian subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 7, pp. 2806–2810, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. M. F. Walsh, M. Barazi, G. Pete, R. Muniyappa, J. C. Dunbar, and J. R. Sowers, “Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide,” Endocrinology, vol. 137, no. 5, pp. 1798–1803, 1996. View at Publisher · View at Google Scholar · View at Scopus
  43. F. Lanfranco, L. Gianotti, R. Giordano, M. Pellegrino, M. Maccario, and E. Arvat, “Ageing, growth hormone and physical performance,” Journal of Endocrinological Investigation, vol. 26, no. 9, pp. 861–872, 2003. View at Google Scholar · View at Scopus
  44. M. H. Rasmussen, A. Juul, and J. Hilsted, “Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism,” Obesity, vol. 15, no. 4, pp. 879–886, 2007. View at Publisher · View at Google Scholar · View at Scopus