Table of Contents
ISRN Genetics
Volume 2014, Article ID 549457, 7 pages
Review Article

The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

1Metabolic Bone Diseases Research Group, University of Extremadura, 10071 Cáceres, Spain
2Departamento de Enfermería, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Avenida Universidad s/n, 10071 Cáceres, Spain

Received 3 October 2013; Accepted 8 December 2013; Published 9 January 2014

Academic Editors: P. A. Fasching and M. Nacak

Copyright © 2014 Jose M. Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to identify, through a systematic review of the literature, Vitamin D receptor gene (VDR) polymorphisms related to osteoporosis and their effects on bone mineral density (BMD). The articles dated between January 2000 and December 2011 in the Scielo and PubMed databases were reviewed. A total of 23 articles that studied the association between the BsmI, ApaI, FokI, and TaqI polymorphisms and bone mineral density in postmenopausal women were selected. We found systematic studies/meta-analysis (level E-I) and case-control/cohort (level E-IV) studies. No definite conclusions can be made regarding the association of BsmI, ApaI, FokI, and TaqI polymorphisms with BMD among postmenopausal women. Larger and more rigorous analytical studies with consideration of gene-gene/environment interactions are needed to further dissect the mechanisms by which VDR alleles influence BMD.