Table of Contents
ISRN Genetics
Volume 2014, Article ID 549457, 7 pages
http://dx.doi.org/10.1155/2014/549457
Review Article

The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

1Metabolic Bone Diseases Research Group, University of Extremadura, 10071 Cáceres, Spain
2Departamento de Enfermería, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Avenida Universidad s/n, 10071 Cáceres, Spain

Received 3 October 2013; Accepted 8 December 2013; Published 9 January 2014

Academic Editors: P. A. Fasching and M. Nacak

Copyright © 2014 Jose M. Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. A. Peck, P. Burckhardt, C. Christiansen et al., “Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis,” American Journal of Medicine, vol. 94, no. 6, pp. 646–650, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. W.-F. Li, S.-X. Hou, B. Yu, M.-M. Li, C. Férec, and J.-M. Chen, “Genetics of osteoporosis: accelerating pace in gene identification and validation,” Human Genetics, vol. 127, no. 3, pp. 249–285, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. C. Christian, P.-L. Yu, C. W. Slemenda, and C. C. Johnston Jr., “Heritability of bone mass: a longitudinal study in aging male twins,” American Journal of Human Genetics, vol. 44, no. 3, pp. 429–433, 1989. View at Google Scholar · View at Scopus
  4. N. A. Pocock, J. A. Eisman, J. L. Hopper, M. G. Yeates, P. N. Sambrook, and S. Eberl, “Genetic determinants of bone mass in adults. A twin study,” Journal of Clinical Investigation, vol. 80, no. 3, pp. 706–710, 1987. View at Google Scholar · View at Scopus
  5. E. Seeman, J. L. Hopper, L. A. Bach et al., “Reduced bone mass in daughters of women with osteoporosis,” The New England Journal of Medicine, vol. 320, no. 9, pp. 554–558, 1989. View at Publisher · View at Google Scholar · View at Scopus
  6. F. A. Tylavsky, A. D. Bortz, R. L. Hancock, and J. J. Anderson, “Familial resemblance of radial bone mass between premenopausal mothers and their college-age daughters,” Calcified Tissue International, vol. 45, no. 5, pp. 265–272, 1989. View at Google Scholar · View at Scopus
  7. J. A. Eisman, “Vitamin D receptor gene alleles and osteoporosis: an affirmative view,” Journal of Bone and Mineral Research, vol. 10, no. 9, pp. 1289–1293, 1995. View at Google Scholar · View at Scopus
  8. J. A. Eisman, N. A. Morrison, P. J. Kelly et al., “Genetics of osteoporosis and vitamin D receptor alleles,” Calcified Tissue International, vol. 56, supplement 1, pp. S48–S49, 1995. View at Google Scholar · View at Scopus
  9. S. H. Ralston and B. de Crombrugghe, “Genetic regulation of bone mass and susceptibility to osteoporosis,” Genes and Development, vol. 20, no. 18, pp. 2492–2506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. R. A. Evans, G. M. Marel, E. K. Lancaster, S. Kos, M. Evans, and S. Y. Wong, “Bone mass is low in relatives of osteoporotic patients,” Annals of Internal Medicine, vol. 109, no. 11, pp. 870–873, 1988. View at Google Scholar · View at Scopus
  11. P. J. Kelly, J. L. Hopper, G. T. Macaskill, N. A. Pocock, P. N. Sambrook, and J. A. Eisman, “Genetic factors in bone turnover,” Journal of Clinical Endocrinology and Metabolism, vol. 72, no. 4, pp. 808–813, 1991. View at Google Scholar · View at Scopus
  12. A. Tokita, P. J. Kelly, T. V. Nguyen et al., “Genetic influences on type I collagen synthesis and degradation: further evidence for genetic regulation of bone turnover,” Journal of Clinical Endocrinology and Metabolism, vol. 78, no. 6, pp. 1461–1466, 1994. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Flicker, J. L. Hopper, L. Rodgers, B. Kaymakci, R. M. Green, and J. D. Wark, “Bone density determinants in elderly women: a twin study,” Journal of Bone and Mineral Research, vol. 10, no. 11, pp. 1607–1613, 1995. View at Google Scholar · View at Scopus
  14. N. A. Morrison, J. C. Qi, A. Tokita et al., “Prediction of bone density from vitamin D receptor alleles,” Nature, vol. 367, no. 6460, pp. 284–287, 1994. View at Publisher · View at Google Scholar · View at Scopus
  15. J. P. Ioannidis, I. Stavrou, T. A. Trikalinos et al., “Association of polymorphisms of the estrogen receptor α gene with bone mineral density and fracture risk in women: a meta-analysis,” Journal of Bone and Mineral Research, vol. 17, no. 11, pp. 2048–2060, 2002. View at Google Scholar · View at Scopus
  16. A. G. Uitterlinden, Y. Fang, J. B. Van Meurs, H. A. Pols, and J. P. Van Leeuwen, “Genetics and biology of vitamin D receptor polymorphisms,” Gene, vol. 338, no. 2, pp. 143–156, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. T. M. Durusu, T. G. Bora, T. D. Uluturk et al., “Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women,” Clinical Rheumatology, vol. 29, no. 11, pp. 1285–1293, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B. M. Melnyk and E. Fineout-Overholt, Evidence-Based Practice in Nursing and Healthcare a Guide to Best Practice, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2005.
  19. R. Whittemore and K. Knafl, “The integrative review: updated methodology,” Journal of Advanced Nursing, vol. 52, no. 5, pp. 546–553, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Li, B. Xi, K. Li, and C. Wang, “Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women,” Molecular Biology Reports, vol. 39, no. 5, pp. 5709–5717, 2012. View at Google Scholar · View at Scopus
  21. A. Thakkinstian, C. D'Este, J. Eisman, T. Nguyen, and J. Attia, “Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study,” Journal of Bone and Mineral Research, vol. 19, no. 3, pp. 419–428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Douroudis, K. Tarassi, G. Ioannidis et al., “Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin,” Maturitas, vol. 45, no. 3, pp. 191–197, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Lisker, M. A. López, S. Jasqui et al., “Association of vitamin D receptor polymorphisms with osteoporosis in Mexican postmenopausal women,” Human Biology, vol. 75, no. 3, pp. 399–403, 2003. View at Google Scholar · View at Scopus
  24. B. L. Langdahl, C. H. Gravholt, K. Brixen, and E. F. Eriksen, “Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures,” European Journal of Clinical Investigation, vol. 30, no. 7, pp. 608–617, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Borjas-Fajardo, M. Zambrano, E. Fernández et al., “Analysis of Bsm I polymorphism of the vitamin D receptor (VDR) gene in Venezuelan female patients living in the state of Zulia with osteoporosis,” Investigacion Clinica, vol. 44, no. 4, pp. 275–282, 2003 (Spanish). View at Google Scholar · View at Scopus
  26. J. G. Kim, J. H. Kwon, S. H. Kim, Y. M. Choi, S. Y. Moon, and J. Y. Lee, “Association between vitamin D receptor gene haplotypes and bone mass in postmenopausal Korean women,” American Journal of Obstetrics and Gynecology, vol. 189, no. 5, pp. 1234–1240, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Y. Chen, W. C. Chen, C. D. Hsu, F. J. Tsai, C. H. Tsai, and C. W. Li, “Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan,” Osteoporosis International, vol. 12, no. 12, pp. 1036–1041, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Marc, J. Preželj, R. Komel, and A. Kocijančič, “Association of vitamin D receptor gene polymorphism with bone mineral density in Slovenian postmenopausal women,” Gynecological Endocrinology, vol. 14, no. 1, pp. 60–64, 2000. View at Google Scholar · View at Scopus
  29. M. G. Stathopoulou, G. V. Z. Dedoussis, G. Trovas et al., “The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake,” Journal of Nutritional Biochemistry, vol. 22, no. 8, pp. 752–757, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Mitra, M. Desai, and K.-H. M. Ikram, “Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian women,” Maturitas, vol. 55, no. 1, pp. 27–35, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Dawson-Hughes, S. S. Harris, and S. Finneran, “Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype,” Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 12, pp. 3657–3661, 1995. View at Google Scholar · View at Scopus
  32. N. A. Morrison, R. Yeoman, P. J. Kelly, and J. A. Eisman, “Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphisms and circulating osteocalcin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 15, pp. 6665–6669, 1992. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Zajíčková, I. Žofková, R. Bahbough, and A. Křepelová, “Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass,” Physiological Research, vol. 51, no. 5, pp. 501–509, 2002. View at Google Scholar · View at Scopus
  34. A. Seremak-Mrozikiewicz, K. Drews, P. M. Mrozikiewicz et al., “Correlation of vitamin D receptor gene (VDR) polymorphism with osteoporotic changes in Polish postmenopausal women,” Neuroendocrinology Letters, vol. 30, no. 4, pp. 540–546, 2009. View at Google Scholar · View at Scopus
  35. A. Falchetti, C. Sferrazza, C. Cepollaro et al., “FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa,” Calcified Tissue International, vol. 80, no. 1, pp. 15–20, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Horst-Sikorska, R. Kalak, A. Wawrzyniak, M. Marcinkowska, L. Celczynska-Bajew, and R. Slomski, “Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures,” Journal of Bone and Mineral Metabolism, vol. 25, no. 5, pp. 310–319, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Bandrés, I. Pombo, M. González-Huarriz, A. Rebollo, G. López, and J. García-Foncillas, “Association between bone mineral density and polymorphisms of the VDR, ERalpha, COL1A1 and CTR genes in Spanish postmenopausal women,” Journal of Endocrinological Investigation, vol. 28, no. 4, pp. 312–321, 2005. View at Google Scholar · View at Scopus
  38. B. S. Duman, R. Tanakol, N. Erensoy, M. Öztürk, and S. Yilmazer, “Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women,” Medical Principles and Practice, vol. 13, no. 5, pp. 260–266, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. H.-Y. Chen, W.-C. Chen, C.-D. Hsu, F.-J. Tsai, and C.-H. Tsai, “Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal women in Taiwan,” Acta Obstetricia et Gynecologica Scandinavica, vol. 81, no. 2, pp. 93–98, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Kurabayashi, H. Matsushita, M. Tomita et al., “Association of vitamin D and estrogen receptor gene polymorphism with the effects of longterm hormone replacement therapy on bone mineral density,” Journal of Bone and Mineral Metabolism, vol. 22, no. 3, pp. 241–247, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Zambrano-Morales, L. Borjas, E. Fernández et al., “Association of the vitamin D receptor gene BBAAtt haplotype with osteoporosis in post-menopausic women,” Investigación Clinica, vol. 49, no. 1, pp. 29–38, 2008 (Spanish). View at Google Scholar · View at Scopus
  42. G. Gong, H. S. Stern, S.-C. Cheng et al., “The association of bone mineral density with vitamin D receptor gene polymorphisms,” Osteoporosis International, vol. 9, no. 1, pp. 55–64, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. T. Yoldemir, D. G. Yavuz, G. Anik, N. Verimli, and M. Erenus, “Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density,” Climacteric, vol. 14, no. 3, pp. 384–391, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Valimaki, R. Tahtela, K. Kainulainen et al., “Relation of collagen type I alpha 1 (COLIA 1) and vitamin D receptor genotypes to bone mass, turnover, and fractures in early postmenopausal women and to hip fractures in elderly people,” European Journal of Internal Medicine, vol. 12, no. 1, pp. 48–56, 2001. View at Publisher · View at Google Scholar · View at Scopus
  45. G. R. Fontova, F. C. Gutiérrez, M. M. Broch et al., “Polymorphism of vitamin D receptor gene, bone mass, and bone turnover among women with postmenopausal osteoporosis,” Revista Clinica Española, vol. 200, no. 4, pp. 198–202, 2000 (Spanish). View at Google Scholar · View at Scopus