The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Table 1

Distribution of studies by the level of evidence and the effect of the BsmI polymorphism.

Level of evidence		𝐵𝑠𝑚𝐼 polymorphism
		Genotype 𝑏𝑏	Genotype 𝐵𝑏	Genotype 𝐵𝐵
E-I				Low values of BMD at femoral head [20] and low BMD values in spine [21].
E-IV	C-C^a	No influence on BMD values [33, 43–45], low BMD values in forearm [22], and high incidence of osteoporosis [23].	No influence on BMD values [33, 43–45] and high incidence of osteoporosis [24].	No influence on BMD values [33, 43–45] and high incidence of osteoporosis [24].
	C^b		Low BMD values in trochanter [26].	Low BMD values in spine [27, 28], low BMD levels in spine with low calcium intake [29], and high incidence of osteoporosis [30].

aCase-control; ^bcohort.