The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Table 2

Distribution of studies by the level of evidence and the effect of the ApaI polymorphism.

Level of evidence		ApaI polymorphism
		Genotype 𝑎𝑎	Genotype 𝐴𝑎	Genotype 𝐴𝐴
E-I				Low BMD values in spine [21].
E-IV	C-C^a	No influence on BMD values [24, 33, 43] and low BMD values in forearm [22].	No influence on BMD values [24, 33, 43].	Weakly connected with susceptibility to osteoporosis [33, 45] and no influence on BMD values [24, 43].

aCase-control; ^bcohort.