The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Table 3

Distribution of studies by the level of evidence and the effect of the FokI polymorphism.

Level of evidence		FokI polymorphism
		Genotype 𝑓𝑓	Genotype 𝐹𝑓	Genotype 𝐹𝐹
E-IV	C-C^a	Low BMD values in spine [35]. Lower values of BMD in hip, after adjusting for age and body mass index [33] and no influence on BMD values [24, 43].	No influence on BMD values [24, 43].	No influence on BMD values [24, 43].
	C^b	Low BMD values in spine [36, 37, 39]. High incidence of osteoporosis [30, 39].

aCase-control; ^bcohort.