The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Table 4

Distribution of studies by the level of evidence and the effect of the TaqI polymorphism.

Level of evidence		TaqI polymorphism
		Genotype 𝑡𝑡	Genotype 𝑇𝑡	Genotype 𝑇𝑇
E-IV	C-C^a	Low BMD values in spine [38] and no influence on BMD values [33, 43].	No influence on BMD values [33, 43].	High risk of osteoporosis in postmenopausal women [34], low BMD values in forearm [22], and no influence on BMD values [33, 43].
	C^b	Low BMD levels in spine with low calcium intake [29] and high incidence of osteoporosis [30].	Low BMD values in spine [26].

aCase-control; ^bcohort.