The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Table 5

Distribution of studies by the level of evidence and the related interactions within VDR gene polymorphisms.

Level of evidence		Interaction of haplotypes on the VDR gene polymorphisms
E-IV	C-C^a	AaBb confers an increased risk of osteoporosis [17], BBAAtt confers a higher risk of osteoporosis [41], and BbaaTT confers a protective effect against osteoporosis [41].
	C^b	bAT homozygote confers low BMD values for the femoral head [36].

aCase-control; ^bcohort.