The Region Centromeric to HLA-C Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis
Table 1
Major polymorphic variants found in this study in patients with psoriasis (PsO) and psoriatic arthritis (PsA).
Marker
PsO
Controls
values
PsA
Controls
values
06
25 (50%)
19 (17%)
<0.00001a
62 (56.4%)
19 (17%)
<0.00001e
MICA-A9
15 (30%)
33 (30%)
NS
66 (60%)
33 (30%)
<0.00001f
MICA-A5.1
18 (36%)
44 (40%)
NS
38 (34.5%)
44 (40%)
NS
MICB-CA20
5 (10%)
9 (8.1%)
NS
15 (13.6%)
9 (8.1%)
NS
07
15 (30%)
33 (30%)
NS
43 (39.1%)
33 (30%)
NS
27
5 (10%)
8 (7.3%)
NS
36 (32.7%)
8 (7.3%)
0.001g
C1_4_4 (384)
28 (56%)
25 (23%)
0.0001b
60 (54.5%)
25 (23%)
0.0001h
OTF3 Hind3
42 (84%)
66 (60%)
0.0033c
73 (66.4%)
66 (60%)
NS
HCR (Pg8)
31 (62%)
28 (25.5%)
<0.00001d
37 (33.6%)
28 (25.5%)
NS
OR 4.8 (2.3–10.1). OR 4.3 (2.1–8.8). OR 3.5 (1.5–8.01). OR 4.8 (2.3–9.7). OR 6.18 (3.32–11.51). OR 3.5 (2.0–6.12). OR 5.9 (2.6–13.4). OR 4.3 (2.2–8.4). There was linkage disequilibrium between 06 and C1_4_4 ().