Therapy of Chronic Myeloid Leukemia: Twilight of the Imatinib Era?

Figure 1

Schematic diagram of the translocation that forms the Philadelphia chromosome and schematic representation of the BCR and ABL genes. The ABL and BCR genes reside on the long arms of the chromosomes 9 and 22, respectively. The fusion BCR/ABL gene is formed within the derivative Philadelphia chromosome as a result of the (9; 22) translocation.