Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine

Table 3

IC₅₀ values of various extracts of B. vulgaris and berberine against the growth rate of promastigote forms of Leishmania major and Leishmania tropica. Data are expressed as the mean ± SD (𝑛=3).

Sample	IC50 value (µg/mL)^a
	L. major	L. tropica
Methanolic extract	12.8±1.17	16.1±1.15
Aqueous extract	22.3±2.51	26.6±2.51
Chloroform extract	19.6±2.08	23.3±2.15
Berberine	2.1±0.05	2.9±0.05
MA^b	8.2±1.15	11.6±0.05

 ^aConcentration of drug that caused 50% of growth inhibition of promastigotes.
^bMeglumine antimoniate (Glucantime) as control drug.