Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine

Table 4

CC₅₀ values of methanolic and aqueous extracts of B. vulgaris and berberine on peritoneal macrophage cells and selectivity index (SI) against promastigote forms of L. major and L. tropica. Data are expressed as the mean ± SD (𝑛=3).

Samples	CC^a50 ± SD (μg/mL)	SI^b
		L. major	L. tropica
Methanolic extract	203.3±3.08	15.9	12.6
Aqueous extract	362.6±4.6	16.3	13.8
Chloroform extract	297.6±4.6	15.2	12.8
Berberine	27.3±2.08	13	9.4

 ^aConcentration of extracts that caused 50% mortality in BALB/c mice peritoneal macrophages.
^bSelectivity index (CC₅₀/IC₅₀).