Table of Contents
ISRN Ophthalmology
Volume 2014, Article ID 608390, 7 pages
http://dx.doi.org/10.1155/2014/608390
Review Article

Present and Possible Therapies for Age-Related Macular Degeneration

1School of Medicine, University of Liverpool, Liverpool L69 3GE, UK
2Ophthalmology Department, University Hospital Aintree, Liverpool L9 7AL, UK

Received 12 February 2014; Accepted 20 March 2014; Published 16 April 2014

Academic Editors: Z. Bashshur, A. Kakehashi, and L. Pierro

Copyright © 2014 Muhammad Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Pascolini and S. P. Mariotti, “Global estimates of visual impairment: 2010,” British Journal of Ophthalmology, vol. 96, no. 5, pp. 614–618, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Congdon, B. O'Colmain, C. C. Klaver et al., “Causes and prevalence of visual impairment among adults in the United States,” Archives of Ophthalmology, vol. 122, no. 4, pp. 477–485, 2004. View at Google Scholar
  3. F. L. Ferris III, C. P. Wilkinson, A. Bird et al., “Clinical classification of age-related macular degeneration,” Ophthalmology, vol. 120, no. 4, pp. 844–851, 2013. View at Google Scholar
  4. L. S. Lim, P. Mitchell, J. M. Seddon, F. G. Holz, and T. Y. Wong, “Age-related macular degeneration,” The Lancet, vol. 379, no. 9827, pp. 1728–1738, 2012. View at Google Scholar · View at Scopus
  5. U. Chakravarthy, J. Evans, and P. J. Rosenfeld, “Age related macular degeneration,” British Medical Journal, vol. 340, p. c981, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. C. G. Owen, Z. Jarrar, R. Wormald, D. G. Cook, A. E. Fletcher, and A. R. Rudnicka, “The estimated prevalence and incidence of late stage age related macular degeneration in the UK,” British Journal of Ophthalmology, vol. 96, no. 5, pp. 752–756, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. D. B. Rein, P. Zhang, K. E. Wirth et al., “The economic burden of major adult visual disorders in the United States,” Archives of Ophthalmology, vol. 124, no. 12, pp. 1754–1760, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. B. A. Syed, J. B. Evans, and L. Bielory, “Wet AMD market,” Nature Reviews Drug Discovery, vol. 11, no. 11, p. 827, 2012. View at Google Scholar
  9. S. L. Fine, J. W. Berger, M. G. Maguire, and A. C. Ho, “Age-related macular degeneration,” The New England Journal of Medicine, vol. 342, no. 7, pp. 483–492, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. H. R. Coleman, C. C. Chan, F. L. Ferris III, and E. Y. Chew, “Age-related macular degeneration,” The Lancet, vol. 372, no. 9652, pp. 1835–1845, 2008. View at Google Scholar
  11. T. H. Tezel, N. S. Bora, and H. J. Kaplan, “Pathogenesis of age-related macular degeneration,” Trends in Molecular Medicine, vol. 10, no. 9, pp. 417–420, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Z. Nowak, “Age-related macular degeneration (AMD): pathogenesis and therapy,” Pharmacological Reports, vol. 58, no. 3, pp. 353–363, 2006. View at Google Scholar · View at Scopus
  13. M. Boulton and P. Dayhaw-Barker, “The role of the retinal pigment epithelium: topographical variation and ageing changes,” Eye, vol. 15, part 3, pp. 384–389, 2001. View at Google Scholar · View at Scopus
  14. A. Iriyama, R. Fujiki, Y. Inoue et al., “A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor,” Journal of Biological Chemistry, vol. 283, no. 18, pp. 11947–11953, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Williams, D. Craig, P. Passmore, and G. Silvestri, “Retinal drusen: harbingers of age, safe havens for trouble,” Age and Ageing, vol. 38, no. 6, pp. 648–654, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Age-Related Eye Disease Study Research Group, “A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8,” Archives of Ophthalmology, vol. 119, no. 10, pp. 1417–1436, 2001. View at Google Scholar
  17. P. T. V. M. de Jong, “Age-related macular degeneration,” The New England Journal of Medicine, vol. 355, no. 14, pp. 1474–1485, 2006. View at Google Scholar
  18. D. H. Anderson, R. F. Mullins, G. S. Hageman, and L. V. Johnson, “A role for local inflammation in the formation of drusen in the aging eye,” American Journal of Ophthalmology, vol. 134, no. 3, pp. 411–431, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. P. L. Penfold, M. C. Madigan, M. C. Gillies, and J. M. Provis, “Immunological and aetiological aspects of macular degeneration,” Progress in Retinal and Eye Research, vol. 20, no. 3, pp. 385–414, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. I. A. Bhutto, D. S. McLeod, T. Hasegawa et al., “Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration,” Experimental Eye Research, vol. 82, no. 1, pp. 99–110, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Das and P. G. McGuire, “Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition,” Progress in Retinal and Eye Research, vol. 22, no. 6, pp. 721–748, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. U. Chakravarthy, C. Augood, G. C. Bentham et al., “Cigarette smoking and age-related macular degeneration in the EUREYE study,” Ophthalmology, vol. 114, no. 6, pp. 1157–1163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Finkel and N. J. Holbrook, “Oxidants, oxidative stress and the biology of ageing,” Nature, vol. 408, no. 6809, pp. 239–247, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. J. R. Evans and J. G. Lawrenson, “Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration,” The Cochrane Database of Systematic Reviews, vol. 11, Article ID CD000254, 2012. View at Google Scholar
  25. E. Y. Chew, T. Clemons, J. P. SanGiovanni et al., “The age-related eye disease study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1),” Ophthalmology, vol. 119, no. 11, pp. 2282–2289, 2012. View at Google Scholar
  26. Ophthalmologists TRCo, “Statement from The Royal College of Ophthalmologists in response to the positive draft final guidance from NICE for Eylea,” http://www.rcophth.ac.uk/news.asp?itemid=1390&itemTitle=College+Statement+in+response+to+the+positive+draft+final+guidance+from+NICE+for+Eylea%AE+for+the+treatment+on+wAMD&section=24&sectionTitle=News2013.
  27. Ophthalmologists TRCo, “Bevacizumab (Avastin) use in medical ophthalmology,” http://www.rcophth.ac.uk/core/core_picker/download.asp?id=11812011.
  28. T. Moutray and U. Chakravarthy, “Age-related macular degeneration: current treatment and future options,” Therapeutic Advances in Chronic Disease, vol. 2, no. 5, pp. 325–331, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. D. M. Brown, P. K. Kaiser, M. Michels et al., “Ranibizumab versus verteporfin for neovascular age-related macular degeneration,” The New England Journal of Medicine, vol. 355, no. 14, pp. 1432–1444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. P. J. Rosenfeld, D. M. Brown, J. S. Heier et al., “Ranibizumab for neovascular age-related macular degeneration,” The New England Journal of Medicine, vol. 355, no. 14, pp. 1419–1431, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. N. M. Bressler, D. S. Boyer, D. F. Williams et al., “Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials,” Retina, vol. 32, no. 9, pp. 1821–1828, 2012. View at Google Scholar
  32. D. F. Martin, M. G. Maguire, S. L. Fine et al., “Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results,” Ophthalmology, vol. 119, no. 7, pp. 1388–1398, 2012. View at Google Scholar
  33. U. Chakravarthy, S. P. Harding, C. A. Rogers et al., “Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial,” The Lancet, vol. 382, no. 9900, pp. 1258–1267, 2013. View at Google Scholar
  34. J. S. Heier, D. Boyer, Q. D. Nguyen et al., “The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing,” Ophthalmology, vol. 118, no. 6, pp. 1098–1106, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. J. S. Heier, D. M. Brown, V. Chong et al., “Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration,” Ophthalmology, vol. 119, no. 12, pp. 2537–2548, 2012. View at Google Scholar
  36. Excellence NIfHaC, “Aflibercept solution for injection for treating wet age-related macular degeneration,” 2013.
  37. S. Schaal, H. J. Kaplan, and T. H. Tezel, “Is There Tachyphylaxis to Intravitreal Anti-Vascular Endothelial Growth Factor Pharmacotherapy in Age-Related Macular Degeneration?” Ophthalmology, vol. 115, no. 12, pp. 2199–2205, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Barak, W. J. Heroman, and T. H. Tezel, “The past, present, and future of exudative age-related macular degeneration treatment,” Middle East African Journal of Ophthalmology, vol. 19, no. 1, pp. 43–51, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. A. J. Augustin, S. Puls, and I. Offermann, “Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone,” Retina, vol. 27, no. 2, pp. 133–140, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Zhang, L. Zhang, and R. N. Weinreb, “Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma,” Nature Reviews Drug Discovery, vol. 11, no. 7, pp. 541–559, 2012. View at Google Scholar
  41. K. Takahashi, Y. Saishin, Y. Saishin, A. G. King, R. Levin, and P. A. Campochiaro, “Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib,” Archives of Ophthalmology, vol. 127, no. 4, pp. 494–499, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. P. A. Campochiaro, “Gene transfer for neovascular age-related macular degeneration,” Human Gene Therapy, vol. 22, no. 5, pp. 523–529, 2011. View at Google Scholar
  43. R. Petrarca, P. U. Dugel, M. Bennett et al., “Macular epiretinal brachytherapy in treated age-related macular degeneration (meritage): month 24 safety and efficacy results,” Retina, 2013. View at Publisher · View at Google Scholar
  44. P. U. Dugel, R. Petrarca, M. Bennett et al., “Macular epiretinal brachytherapy in treated age-related macular degeneration. MERITAGE study: twelve-month safety and efficacy results,” Ophthalmology, vol. 119, no. 7, pp. 1425–1431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. P. U. Dugel, J. D. Bebchuk, J. Nau et al., “Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET),” Ophthalmology, vol. 120, no. 2, pp. 317–327, 2013. View at Google Scholar
  46. T. L. Jackson, U. Chakravarthy, P. K. Kaiser et al., “Stereotactic radiotherapy for neovascular age-related macular degeneration: 52-week safety and efficacy results of the INTREPID study,” Ophthalmology, vol. 120, no. 9, pp. 1893–1900, 2013. View at Google Scholar
  47. J. C. Lai, D. J. Lapolice, S. S. Stinnett et al., “Visual outcomes following macular translocation with 360° peripheral retinectomy,” Archives of Ophthalmology, vol. 120, no. 10, pp. 1317–1324, 2002. View at Google Scholar · View at Scopus
  48. C. I. Falkner-Radler, I. Krebs, C. Glittenberg et al., “Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study,” British Journal of Ophthalmology, vol. 95, no. 3, pp. 370–375, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. T. H. Tezel and L. V. del Priore, “Repopulation of different layers of host human Bruch's membrane by retinal pigment epithelial cell grafts,” Investigative Ophthalmology and Visual Science, vol. 40, no. 3, pp. 767–774, 1999. View at Google Scholar · View at Scopus
  50. S. D. Schwartz, J.-P. Hubschman, G. Heilwell et al., “Embryonic stem cell trials for macular degeneration: a preliminary report,” The Lancet, vol. 379, no. 9817, pp. 713–720, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. Z. Yehoshua, P. J. Rosenfeld, and T. A. Albini, “Current clinical trials in dry AMD and the definition of appropriate clinical outcome measures,” Seminars in Ophthalmology, vol. 26, no. 3, pp. 167–180, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. S.-Y. Cohen, H. Bourgeois, C. Corbe et al., “Randomized clinical trial france DMLA2: effect of trimetazidine on exudative and nonexudative age-related macular degeneration,” Retina, vol. 32, no. 4, pp. 834–843, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. N. L. Mata, J. B. Lichter, R. Vogel, Y. Han, T. V. Bui, and L. J. Singerman, “Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration,” Retina, vol. 33, no. 3, pp. 498–507, 2013. View at Google Scholar
  54. R. Kubota, N. L. Boman, R. David, S. Mallikaarjun, S. Patil, and D. Birch, “Safety and effect on rod function of ACU-4429, a novel small-molecule visual cycle modulator,” Retina, vol. 32, no. 1, pp. 183–188, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. D. McNamara, “Lampalizumab Appears Safe for Dry Macular Degeneration Medscape 2013,” http://www.medscape.com/viewarticle/811878.