Epidemiologic Behavior and Estimation of an Optimal Cut-Off Point for Homeostasis Model Assessment-2 Insulin Resistance: A Report from a Venezuelan Population

Table 5

HOMA2-IR cut-off points based on ROC curves, sensitivity, specificity, Youden’s index, positive likelihood, and distance to the ROC curve. The Maracaibo City Metabolic Syndrome Prevalence Study, 2014.

	HOMA2-IR	Sensitivity (%)	Specificity (%)	Youden’s index	Distance to ROC	LR+
Women	2.05	68.0	73.0	0.41^Ψ	0.41	2.51
	1.95	72.5	67.7	0.40	0.42	2.24
	1.85	75.8	63.2	0.39	0.44	2.05
Men	2.05	75.3	81.4	0.57^Ψ	0.30	4.04
	1.95	77.9	77.3	0.55	0.31	3.43
	1.85	79.6	74.4	0.46	0.32	3.11
All	2.05	71.8	77.4	0.49^Ψ	0.36	3.17
	1.95	75.3	72.8	0.48	0.37	2.76
	1.85	77.8	69.1	0.47	0.38	2.51

Selected cut-off (HOMA2-IR) based on sensitivity, specificity, Youden’s index, and positive likelihood ratios (LR+), giving emphasis to highest sensitivity values.
^ΨCut-off 1 asserted using the maximum Youden’s index.
Cut-off 2 obtained from the point closest to ROC (0.1).