Efficient Electrochemical N-Alkylation of N-Boc-Protected 4-Aminopyridines: Towards New Biologically Active Compounds

Table 2

Alkylation reaction of 4-alkylaminopyridines with 𝑡-BuOK in DMSO^a.

Entry	Starting 2	R′–X	3, yield^b
1
2
3
4

a1 mmol of 2 in 2 mL of anhydrous DMSO, at rt, under N₂. Then 1.5 mmol of 𝑡-BuOK were added, followed by 1 mmol of halide after 20 min. The reaction was kept under stirring for 4 h. ^bAll the yields are in isolated products.