Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 628382, 6 pages
Research Article

Study of the Effect of Dillenia indica Fruit Mucilage on the Properties of Metformin Hydrochloride Loaded Spray Dried Microspheres

Department of Pharmaceutical Sciences, Dibrugarh University, NH-37, Dibrugarh, Assam 786004, India

Received 20 May 2014; Revised 7 September 2014; Accepted 5 November 2014; Published 20 November 2014

Academic Editor: Hamadi Fetoui

Copyright © 2014 Hemanta Kumar Sharma and Lila Kanta Nath. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Natural materials are preferred over synthetic counterparts because of their biodegradable and biocompatible nature. The present work was proposed to utilize mucilage from natural source for the development of controlled release formulation of metformin hydrochloride. Natural mucilaginous substance extracted from Dillenia indica L. (DI) fruit was used in fabricating controlled release microspheres. The microspheres were prepared by spray drying method under different formulation parameters. The prepared microspheres were studied for particle size, drug excipient compatibility, particle shape and surface morphologies, drug entrapment efficiency, mucoadhesivity, and in vitro drug release properties. The prepared microspheres exhibited mucoadhesive properties and demonstrated controlled release of metformin hydrochloride. The study reveals that the natural materials can be used for formulation of controlled release microspheres and would provide ample opportunities for further study.