Study of the Effect of Dillenia indica Fruit Mucilage on the Properties of Metformin Hydrochloride Loaded Spray Dried Microspheres

Table 2

In vitro evaluation of the metformin hydrochloride loaded spray dried microspheres prepared using mucilage of D. indica.

Formulation code	Mean particle size (µm) ± SD; = 80	Drug entrapment; efficiency (%) ± SD;	Liquid uptake capacity in different media (%) ± SD; = 3
			0.1 M HCl	Water	Phosphate buffer (pH 7.4)
SD1	62 ± 4.09	43.67 ± 0.58	12 ± 1.22	26 ± 0.39	42 ± 1.07
SD2	69 ± 2.34	44.02 ± 1.05	16 ± 0.55	32 ± 0.60	44 ± 0.66
SD3	78 ± 4.24	47.05 ± 2.01	20 ± 0.74	48 ± 0.62	48 ± 0.23
SD4	76 ± 3.58	43.74 ± 1.24	10 ± 0.82	22 ± 0.22	42 ± 0.08
SD5	77 ± 1.08	45.13 ± 0.83	12 ± 0.19	16 ± 0.23	43 ± 0.26
SD6	85 ± 4.06	49.84 ± 1.68	28 ± 0.41	50 ± 0.39	54 ± 0.14
SD7	83 ± 3.34	44.78 ± 1.09	12 ± 0.34	42 ± 0.42	52 ± 0.22
SD8	84 ± 2.18	46.03 ± 2.01	28 ± 0.29	24 ± 0.37	57 ± 0.14
SD9	93 ± 3.87	53.17 ± 1.06	18 ± 0.25	52 ± 0.11	62 ± 0.92
SD10	78 ± 3.47	47.33 ± 1.57	17 ± 0.25	22 ± 0.53	48 ± 0.55
SD11	85 ± 2.11	52.73 ± 1.23	11 ± 0.24	18 ± 0.62	45 ± 0.64
SD12	98 ± 4.13	55.12 ± 1.83	28 ± 0.14	54 ± 0.13	66 ± 0.05