Safety Evaluation of Zingiber cassumunar Roxb. Rhizome Extract: Acute and Chronic Toxicity Studies in Rats

Table 3

Body weights (g) of rats treated with Z. cassumunar extract granules in chronic oral toxicity study^a.

Dose (mg/kg bw/d)	Day 0	Day 90	Day 180	Day 270	Day 298	Weight gain at day 270
Female
0	220.50 ± 4.10	312.5 ± 6.93	357.50 ± 9.50	392.00 ± 3.75		171.50 ± 2.71
0.3	218.50 ± 1.38	302.50 ± 4.03	353.50 ± 7.27	386.50 ± 5.74		168.00 ± 4.57
3.0	229.5 0 ± 2.29	302.00 ± 7.04	353.50 ± 11.76	388.00 ± 4.85		158.50 ± 5.08
30	221.50 ± 4.83	310.00 ± 5.47	350.00 ± 4.64	385.50 ± 7.14		164.00 ± 2.64
30^b	218.00 ± 7.67	310.00 ± 7.67	349.00 ± 7.67	383.50 ± 3.97	400.50 ± 4.73	165.50 ± 7.03
11.25	226.50 ± 3.02	307.50 ± 5.19	353.00 ± 7.67	391.00 ± 3.82		164.50 ± 2.14
112.5	225.50 ± 11.76	305.50 ± 11.76	353.50 ± 11.76	389.50 ± 4.25		164.00 ± 3.45
1,125	225.00 ± 4.64	317.00 ± 4.64	357.00 ± 4.64	387.00 ± 5.04		162.00 ± 3.02
1,125^b	217.00 ± 7.67	308.00 ± 7.67	356.00 ± 7.67	386.50 ± 2.94	403.50 ± 5.31	169.50 ± 4.62
Male
0	261.00 ± 4.10	529.00 ± 7.81	605.50 ± 6.93	685.50 ± 5.63		424.50 ± 2.10
0.3	258.50 ± 1.38	506.00 ± 5.64	580.50 ± 4.03	640.50 ± 2.53		382.00 ± 1.98
3.0	253.50 ± 2.29	521.50 ± 4.89	600.00 ± 7.04	675.00 ± 5.14		421.50 ± 3.19
30	253.50 ± 4.83	524.00 ± 4.42	599.00 ± 5.47	676.50 ± 3.67		423.00 ± 3.73
30^b	248.50 ± 3.02	544.50 ± 4.47	607.50 ± 5.19	677.50 ± 3.49	697.50 ± 4.01	429.00 ± 2.12
11.25	262.50 ± 3.02	529.50 ± 4.47	602.50 ± 5.19	682.50 ± 4.29		420.00 ± 1.52
112.5	266.00 ± 3.05	533.00 ± 6.86	616.50 ± 5.64	676.50 ± 4.34		410.50 ± 1.35
1,125	268.50 ± 3.69	523.50 ± 4.62	592.50 ± 6.20	682.50 ± 3.20		414.00 ± 1.96
1,125^b	250.00 ± 4.36	519.00 ± 9.95	597.00 ± 11.62	677.00 ± 5.82	698.50 ± 3.24	427.00 ± 3.46

Values are expressed as mean ± SEM (n = 10 for each group).
^bSatellite groups were treated with Z. cassumunar extract granules at the indicated dose for 270 days followed by no treatment for 28 days.