International Scholarly Research Notices / 2014 / Article / Tab 3

Research Article

Safety Evaluation of Zingiber cassumunar Roxb. Rhizome Extract: Acute and Chronic Toxicity Studies in Rats

Table 3

Body weights (g) of rats treated with Z. cassumunar extract granules in chronic oral toxicity studya.

Dose (mg/kg bw/d)Day 0Day 90Day 180Day 270Day 298Weight gain at day 270

Female
 0220.50 ± 4.10312.5 ± 6.93357.50 ± 9.50392.00 ± 3.75171.50 ± 2.71
 0.3218.50 ± 1.38 302.50 ± 4.03353.50 ± 7.27386.50 ± 5.74168.00 ± 4.57
 3.0229.5 0 ± 2.29302.00 ± 7.04353.50 ± 11.76388.00 ± 4.85158.50 ± 5.08
 30221.50 ± 4.83310.00 ± 5.47350.00 ± 4.64385.50 ± 7.14164.00 ± 2.64
 30b218.00 ± 7.67310.00 ± 7.67349.00 ± 7.67383.50 ± 3.97400.50 ± 4.73165.50 ± 7.03
 11.25226.50 ± 3.02307.50 ± 5.19353.00 ± 7.67391.00 ± 3.82164.50 ± 2.14
 112.5225.50 ± 11.76305.50 ± 11.76353.50 ± 11.76389.50 ± 4.25164.00 ± 3.45
 1,125225.00 ± 4.64317.00 ± 4.64357.00 ± 4.64387.00 ± 5.04162.00 ± 3.02
 1,125b217.00 ± 7.67308.00 ± 7.67356.00 ± 7.67386.50 ± 2.94403.50 ± 5.31169.50 ± 4.62
Male
 0261.00 ± 4.10529.00 ± 7.81605.50 ± 6.93685.50 ± 5.63424.50 ± 2.10
 0.3258.50 ± 1.38506.00 ± 5.64580.50 ± 4.03640.50 ± 2.53382.00 ± 1.98
 3.0253.50 ± 2.29521.50 ± 4.89600.00 ± 7.04675.00 ± 5.14421.50 ± 3.19
 30253.50 ± 4.83524.00 ± 4.42599.00 ± 5.47676.50 ± 3.67423.00 ± 3.73
 30b248.50 ± 3.02544.50 ± 4.47607.50 ± 5.19677.50 ± 3.49697.50 ± 4.01429.00 ± 2.12
 11.25262.50 ± 3.02529.50 ± 4.47602.50 ± 5.19682.50 ± 4.29420.00 ± 1.52
 112.5266.00 ± 3.05533.00 ± 6.86616.50 ± 5.64676.50 ± 4.34410.50 ± 1.35
 1,125268.50 ± 3.69523.50 ± 4.62592.50 ± 6.20682.50 ± 3.20414.00 ± 1.96
 1,125b250.00 ± 4.36519.00 ± 9.95597.00 ± 11.62677.00 ± 5.82698.50 ± 3.24427.00 ± 3.46

Values are expressed as mean ± SEM (n = 10 for each group).
bSatellite groups were treated with Z. cassumunar extract granules at the indicated dose for 270 days followed by no treatment for 28 days.

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