International Scholarly Research Notices / 2014 / Article / Tab 4

Research Article

Safety Evaluation of Zingiber cassumunar Roxb. Rhizome Extract: Acute and Chronic Toxicity Studies in Rats

Table 4

Absolute organ weights (g) of rats treated with Z. cassumunar extract granules in chronic oral toxicity studya.

OrganDose (mg/kg bw/d)
00.33.03030b11.25112.51,1251,125b

Female
 Brain1.94 ± 0.021.93 ± 0.031.98 ± 0.031.91 ± 0.031.90 ± 0.021.96 ± 0.031.93 ± 0.021.90 ± 0.021.90 ± 0.02
 Lungs2.18 ± 0.142.16 ± 0.152.43 ± 0.242.08 ± 0.152.00 ± 0.222.31 ± 0.272.29 ± 0.142.35 ± 0.262.30 ± 0.31
 Heart1.24 ± 0.031.31 ± 0.031.30 ± 0.031.29 ± 0.031.35 ± 0.061.31 ± 0.031.46 ± 0.05*1.37 ± 0.03*1.21 ± 0.04
 Livers9.12 ± 0.8810.12 ± 0.219.84 ± 0.4610.06 ± 0.2310.17 ± 0.2410.32 ± 0.319.77 ± 0.379.42 ± 0.299.38 ± 0.29
 Spleen0.81 ± 0.040.81 ± 0.040.84 ± 0.040.78 ± 0.050.76 ± 0.020.73 ± 0.040.70 ± 0.01*0.74 ± 0.040.72 ± 0.03*
 Adrenals0.04 ± 0.000.06 ± 0.020.04 ± 0.000.04 ± 0.000.03 ± 0.000.04 ± 0.000.04 ± 0.000.04 ± 0.000.03 ± 0.00
 Kidneys1.32 ± 0.021.29 ± 0.021.25 ± 0.03*1.25 ± 0.02*1.24 ± 0.02*1.27 ± 0.021.29 ± 0.021.28 ± 0.021.20 ± 0.02*
 Ovary0.06 ± 0.000.06 ± 0.000.06 ± 0.010.07 ± 0.000.06 ± 0.010.06 ± 0.000.06 ± 0.020.06 ± 0.000.05 ± 0.00
 Uterus1.36 ± 0.311.34 ± 0.171.51 ± 0.342.71 ± 0.532.31 ± 0.811.19 ± 0.071.17 ± 0.131.45 ± 0.291.33 ± 0.12
Male
 Brain2.04 ± 0.052.03 ± 0.032.05 ± 0.042.04 ± 0.032.12 ± 0.022.06 ± 0.021.98 ± 0.052.05 ± 0.022.04 ± 0.02
 Lung2.74 ± 0.312.79 ± 0.192.73 ± 0.223.52 ± 0.36*2.70 ± 0.132.63 ± 0.272.79 ± 0.142.75 ± 0.262.63 ± 0.31
 Heart1.78 ± 0.031.70 ± 0.041.82 ± 0.061.96 ± 0.08*2.09 ± 0.04*1.71 ± 0.031.73 ± 0.051.77 ± 0.031.81 ± 0.04
 Livers17.79 ± 0.5517.02 ± 0.9216.77 ± 0.5517.38 ± 1.1118.57 ± 0.7617.32 ± 0.3116.77 ± 0.3717.42 ± 0.2917.38 ± 0.29
 Spleen1.01 ± 0.031.02 ± 0.041.00 ± 0.041.02 ± 0.061.05 ± 0.031.03 ± 0.041.07 ± 0.01*1.04 ± 0.041.02 ± 0.03
 Adrenals 0.03 ± 0.020.03 ± 0.000.03 ± 0.000.03 ± 0.000.04 ± 0.000.04 ± 0.000.04 ± 0.000.04 ± 0.000.03 ± 0.00
 Kidneys1.78 ± 0.051.88 ± 0.051.92 ± 0.06*1.87 ± 0.062.05 ± 0.04*1.77 ± 0.021.79 ± 0.021.88 ± 0.021.82 ± 0.02
 Testes2.01 ± 0.042.04 ± 0.022.02 ± 0.032.07 ± 0.052.08 ± 0.032.06 ± 0.032.08 ± 0.052.06 ± 0.042.05 ± 0.06
 Epididymis0.88 ± 0.030.85 ± 0.010.85 ± 0.020.83 ± 0.030.84 ± 0.010.94 ± 0.070.87 ± 0.030.95 ± 0.090.83 ± 0.02

Values are expressed as mean ± SEM (n = 10 for each group).
bSatellite groups were treated with Z. cassumunar extract at the indicated dose for 270 days followed by no treatment for 28 days.
values < 0.05, compared to the corresponding control.

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