Table of Contents
ISRN Nephrology
Volume 2014 (2014), Article ID 634515, 7 pages
Clinical Study

Effect of α-Lipoic Acid on Oxidative Stress in End-Stage Renal Disease Patients Receiving Intravenous Iron

1Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Suite B224, Memphis, TN 38163, USA
2Emergency Department, Methodist Affiliated Hospitals, Memphis, TN 38163, USA
3Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

Received 13 December 2013; Accepted 29 January 2014; Published 5 March 2014

Academic Editors: A. Arduini, E. Costa, and L. Djukanovic

Copyright © 2014 Arif Showkat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress is associated with increased risk of cardiovascular disease in end-stage renal disease (ESRD) patients. Intravenous (IV) iron has been shown to increase oxidative stress. The aim of the study was to evaluate changes in oxidative stress markers following administration of IV sodium ferric gluconate (SFG) to ESRD patients with and without administration of the antioxidant, α-lipoic acid. This is an open-label, crossover study. 125 mg of IV SFG was administered during control (C) and intervention (I) visits. During the I visit, 600 mg of α-lipoic acid was given orally prior to IV SFG. Blood samples were collected at defined time periods for F2-isoprostane (FIP), lipid hydroperoxide (LHP), malondialdehyde (MDA), and iron indices. We recruited ten African-American ESRD subjects: 50% male; mean age years; mean hemoglobin  g/dL; ferritin  ng/mL; transferrin saturation %. There were no significant differences in iron indices between the two visits after IV SFG. MDA, FIP, and LHP increased significantly for both C and I visits with a greater increase in the I group. Administration of IV SFG results in an acute rise in oxidative stress in ESRD patients. In contrast to previous studies, administration of α-lipoic acid was associated with a greater increase in oxidative stress.